Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13231
Abstract: N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of Nε‐methylated lysine 26 on histone 1 isotype 4 (H1.4).… read more here.
Keywords: kdm catalysed; demethylation; structural studies; catalysed demethylation ... See more keywords
Structural studies on M. tuberculosis argininosuccinate lyase and its liganded complex: Insights into catalytic mechanism
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2000
Abstract: Argininosuccinate lyase catalyses the reversible breakdown of argininosuccinate into arginine and fumarate and is known to form tetramers in its quaternary association. The absence of structures involving competent enzymes bound to substrate/products came in the… read more here.
Keywords: studies tuberculosis; mechanism; catalytic mechanism; structural studies ... See more keywords
Structural studies of antitumor compounds that target the RING domain of MDM2
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4367
Abstract: Mouse double minute 2 homolog (MDM2) is an E3 ubiquitin‐protein ligase that is involved in the transfer of ubiquitin to p53 and other protein substrates. The expression of MDM2 is elevated in cancer cells and… read more here.
Keywords: structural studies; mdm2; mdm2 ring; ring domain ... See more keywords
Complementary Use of Electron Cryomicroscopy and X-Ray Crystallography: Structural Studies of Actin and Actomyosin Filaments.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-2200-6_4
Abstract: Visualization of macromolecular structures is essential for understanding the mechanisms of biological functions because they are all determined by the structure and dynamics of macromolecular complexes. Electron cryomicroscopy (cryoEM) and image analysis has become a… read more here.
Keywords: electron cryomicroscopy; structural studies; ray crystallography; biology ... See more keywords
Synthesis and purification of linkage-specific polyubiquitin chains of distinct length for structural studies.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.08.007
Abstract: Polyubiquitylation is one of the most versatile post-translational modifications involved in the regulation of numerous intracellular signaling processes. An assembly procedure that is simple, robust, and efficient to synthesize and purify linkage-specific polyubiquitin chains of… read more here.
Keywords: structural studies; linkage specific; polyubiquitin chains; specific polyubiquitin ... See more keywords
Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.07.011
Abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the hallmarks of AD. Several lines of evidence have shown a… read more here.
Keywords: aggregation; mechanism; amyloid peptides; structural studies ... See more keywords
Structural Studies of Overlapping Dinucleosomes in Solution
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2019.12.010
Abstract: An overlapping dinucleosome (OLDN) is a structure composed of one hexasome and one octasome and appears to be formed through nucleosome collision promoted by nucleosome remodeling factor(s). In this study, the solution structure of the… read more here.
Keywords: studies overlapping; structural studies; structure; overlapping dinucleosomes ... See more keywords
Structural studies of the O-specific polysaccharide from detergent degrading bacteria Pseudomonas putida TSh-18.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate research"
DOI: 10.1016/j.carres.2017.05.013
Abstract: An O-specific polysaccharide was obtained by mild acid degradation of the lipopolysaccharide of bacteria Pseudomonas putida TSh-18, capable of degrading non-ionogenic technical detergents. The polysaccharide was found to contain a rarely occurring sugar derivative 4,6-dideoxy-4-[(R)-3-hydroxybutanoylamino]-d-galactose… read more here.
Keywords: putida tsh; specific polysaccharide; pseudomonas putida; structural studies ... See more keywords
DFT and structural studies of 2-oxo-1,2,3,4-tetrahydropyridines
Sign Up to like & getrecommendations! Published in 2017 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2016.11.018
Abstract: Abstract Quantum chemical calculations based on density functional theory (DFT) and X-ray crystal structure analysis of some ethyl 4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylates (THPYs) were applied in order to elucidate the effect of variations of the additional substituent on… read more here.
Keywords: studies oxo; structural studies; oxo tetrahydropyridines; geometry ... See more keywords
Structural studies of bis(histidinato)nickel(II): Combined experimental and computational studies
Sign Up to like & getrecommendations! Published in 2017 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2016.12.006
Abstract: Abstract A distorted octahedral nickel(II) complex, [Ni(2-amino-3-(1H-imidazol-4-yl)propanoic acid)2] (1), has been synthesized by a solvothermal method and characterized by single-crystal X-ray diffraction. Geometry optimization in the gas phase and pyridine together with Hirshfeld surface and… read more here.
Keywords: nickel; studies bis; structural studies; histidinato nickel ... See more keywords
Structural studies of a new fraction obtained by gradient ethanol precipitation from Acacia seyal gum
Sign Up to like & getrecommendations! Published in 2020 at "Food Hydrocolloids"
DOI: 10.1016/j.foodhyd.2020.105932
Abstract: Abstract AY60 was a fraction precipitated from Acacia seyal gum by 60% ethanol, and its detailed structure was elucidated by methylation analysis and 1D/2D NMR spectroscopy. AY60 (Mw~92.4 kDa) was found to be a highly branched… read more here.
Keywords: acacia seyal; seyal gum; structural studies; spectroscopy ... See more keywords