Identification and accurate quantification of structurally related peptide impurities in synthetic human C-peptide by liquid chromatography–high resolution mass spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1155-y
Abstract: AbstractPeptides are an increasingly important group of biomarkers and pharmaceuticals. The accurate purity characterization of peptide calibrators is critical for the development of reference measurement systems for laboratory medicine and quality control of pharmaceuticals. The… read more here.
Keywords: peptide; peptide impurities; mass; related peptide ... See more keywords
Synthesis of oligosaccharides structurally related to fragments of Streptococcus pneumoniae type 3 capsular polysaccharide
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1708-9
Abstract: Abstract3-Aminopropyl glycosides of di-, tri-, and tetrasaccharide structurally related to fragments of Streptococcus pneumoniae type 3 bacteria capsular polysaccharide were synthesized. read more here.
Keywords: pneumoniae type; fragments streptococcus; structurally related; streptococcus pneumoniae ... See more keywords
Influence of structurally related micelle forming surfactants on the antioxidant activity of natural substances.
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2019.104818
Abstract: Physicochemical properties of micelles, like other lipid aggregates, mostly depend on the composition and on the structure of the surfactants used as monomers. The preparation and the characterization of three cationic L-prolinol derivative surfactants with… read more here.
Keywords: chain; antioxidant activity; influence structurally; structurally related ... See more keywords
Transcriptome analysis of two structurally related flavonoids; Apigenin and Chrysin revealed hypocholesterolemic and ketogenic effects in mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173804
Abstract: There is no known single therapeutic drug for treating hypercholesterolemia that comes with negligible systemic side effects. In the current study, using next generation RNA sequencing approach in mouse embryonic fibroblasts we discovered that two… read more here.
Keywords: embryonic fibroblasts; two structurally; chrysin; apigenin chrysin ... See more keywords
Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.05.055
Abstract: Abstract As a well-known herb worldwide, rhubarb presents a wide range of pharmacological activities. In our studies, Rheum palmatum L. extracts and five isolated anthraquinones possessed insecticidal activity. The acetone extract (yield, 8.84%), which contained… read more here.
Keywords: insecticidal activity; structurally related; activity; rheum palmatum ... See more keywords
The binding orientations of structurally-related ligands can differ; A cautionary note
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.01.023
Abstract: ABSTRACT Crystal structures can identify ligand‐receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5‐HT3 and &agr;7 nACh… read more here.
Keywords: binding orientations; nach receptors; agr nach; structurally related ... See more keywords
Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.07.012
Abstract: The amount of antibody (Ab) variable gene sequence information is expanding rapidly, but our ability to predict the function of Abs from sequence alone is limited. Here, we describe a sequence-to-function prediction method that couples… read more here.
Keywords: structurally related; identification structurally; structure; position specific ... See more keywords
Efficient Crystal Structure Prediction for Structurally Related Molecules with Accurate and Transferable Tailor-Made Force Fields
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c00451
Abstract: Crystal structure prediction (CSP) is generally used to complement experimental solid form screening and applied to individual molecules in drug development. The fast development of algorithms and computing resources offers the opportunity to use CSP… read more here.
Keywords: csp; related molecules; structurally related; force ... See more keywords
Structurally Related Liposomes Containing N-Oxide Surfactants: Physicochemical Properties and Evaluation of Antimicrobial Activity in Combination with Therapeutically Available Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00609
Abstract: Although liposomes are largely investigated as drug delivery systems, they can also exert a pharmacological activity if devoid of an active principle as a function of their composition. Specifically, charged liposomes can electrostatically interact with… read more here.
Keywords: oxide surfactants; related liposomes; containing oxide; structurally related ... See more keywords
A Comparative Study on the Performance of Inert and Functionalized Spheres Coated with Solid Dispersions Made of Two Structurally Related Antifungal Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00482
Abstract: Fluid bed coating offers potential advantages as a formulation platform for amorphous solid dispersions (ASDs) of poorly soluble drugs, being a one-step manufacturing process which could reduce the risk of phase separation associated with multiple… read more here.
Keywords: two structurally; microscopy; pos; solid dispersions ... See more keywords
A sustainable strategy for the assembly of Glypromate® and its structurally-related analogues by tandem sequential peptide coupling
Sign Up to like & getrecommendations! Published in 2020 at "Green Chemistry"
DOI: 10.1039/d0gc00143k
Abstract: This work describes an improved and greener methodology of solution-phase synthesis for the preparation of Glypromate® (glycyl-L-prolyl-L-glutamic acid, GPE), a potent neuropeptide for applications in neurodegenerative conditions such as Huntington's, Parkinson's and Alzheimer's diseases. This… read more here.
Keywords: peptide; sequential peptide; structurally related; glypromate ... See more keywords