Asymmetric Synthesis of Structurally Sophisticated Spirocyclic Pyrano[2,3-c]pyrazole Derivatives Bearing a Chiral Quaternary Carbon Center.
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DOI: 10.1021/acs.orglett.2c02211
Abstract: A carbene-catalyzed enantio- and diastereoselective [2 + 4] cycloaddition reaction is developed for quick and efficient access to structurally complex multicyclic pyrano[2,3-c]pyrazole molecules. The reaction tolerates a broad scope of substrates bearing various substitution patterns,… read more here.
Keywords: synthesis structurally; structurally sophisticated; pyrano; pyrano pyrazole ... See more keywords