Synthesis and structure-affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103658
Abstract: A novel set of pyrrolidinone-based chlorinated benzenesulfonamide derivatives were synthesized and investigated for their binding affinity and selectivity against recombinant human carbonic anhydrases I-XIV using fluorescent thermal shift, p-nitrophenyl acetate hydrolysis and stopped-flow enzymatic inhibition… read more here.
Keywords: affinity relationship; human carbonic; affinity; pyrrolidinone ... See more keywords
Integrated multispectroscopic analysis and molecular docking analyses of the structure-affinity relationship and mechanism of the interaction of flavonoids with zein.
Sign Up to like & getrecommendations! Published in 2022 at "Food chemistry"
DOI: 10.1016/j.foodchem.2022.132839
Abstract: Zein is a desired carrier to construct a delivery system for flavonoids. However, studies examining the binding of flavonoids with zein are still inadequate. Therefore, the structure-affinity relationship and mechanism underlying the interaction between flavonoids… read more here.
Keywords: structure affinity; structure; affinity relationship; flavonoids zein ... See more keywords
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors.
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DOI: 10.2139/ssrn.4310437
Abstract: The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, tritium-labeled YM and FR derivatives display largely different… read more here.
Keywords: protein inhibitors; structure; structure affinity; residence ... See more keywords