A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity
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DOI: 10.1080/15257770.2017.1322209
Abstract: ABSTRACT Synthesis of a novel 2′-deoxy-guanine carbocyclic nucleoside 4 constructed with spiro[2.4]heptane core structure in the aglycon moiety was carried out. Radical-mediated 5-exo-dig mode cyclization and following cyclopropanation proceeded efficiently to furnish the spiro alcohol… read more here.
Keywords: aglycon moiety; heptane core; spiro heptane; core structure ... See more keywords