The Impact of Secondary Structure on the Base‐Filling of N‐Methoxy‐1,3‐Oxazinane (MOANA) and N‐Methoxy‐1,3‐Oxazolidine Glycol Nucleic Acid (MOGNA) Oligonucleotides
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DOI: 10.1002/cbic.202400666
Abstract: Various single‐stranded and hairpin‐forming DNA and 2'‐O‐methyl‐RNA oligonucleotides bearing a single (2R,3S)‐4‐(methoxyamino)butane‐1,2,3‐triol residue esterified from either O1 and O2 or O1 and O3 were synthesized. Incubation of these oligonucleotides with equimolar mixtures of formylmethyl derivatives… read more here.
Keywords: impact secondary; filling methoxy; structure base; secondary structure ... See more keywords
Structure-base design to explore the anticancer efficacy of organometallic Pt(II)- and Au(III)-N-heterocyclic carbene (NHC) complexes
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DOI: 10.1039/d4nj02853h
Abstract: Cancer is one of the leading public health concerns globally; therefore it is required better drugs for treatment. Several strategies have been taken to improve the success of drug discovery.... read more here.
Keywords: design explore; anticancer efficacy; explore anticancer; efficacy organometallic ... See more keywords