The preparation, characterization, structure and dissolution analysis of apremilast solvatomorphs.
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DOI: 10.1107/s2053229617002984
Abstract: Apremilast (AP) {systematic name: (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4-acetamidoisoindoline-1,3-dione} is an inhibitor of phosphodieasterase-4 (PDE4) and is indicated for the treatment of adult patients with active psoriatic arthritis. The ability of AP to form solvates has been investigated and… read more here.
Keywords: characterization structure; analysis; structure dissolution; three solvatomorphs ... See more keywords