Recent insights into the structure and function of coronavirus ribonucleases
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13414
Abstract: Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS‐CoV‐2 pandemic has led… read more here.
Keywords: insights structure; recent insights; structure function; coronavirus ribonucleases ... See more keywords
Establishing Self‐Dopant Design Principles from Structure–Function Relationships in Self‐n‐Doped Perylene Diimide Organic Semiconductors (Adv. Mater. 42/2022)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202204656
Abstract: Self-doping is a particular doping method that has been applied to a wide range of organic semiconductors. However, there is a lack of understanding regarding the relationship between dopant structure and function. We investigated a… read more here.
Keywords: structure function; self dopant; organic semiconductors; doped perylene ... See more keywords
Extracellular Adhesive Cues Physically Define Nucleolar Structure and Function
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DOI: 10.1002/advs.202105545
Abstract: Adhesive cues from the extracellular matrix (ECM) specify the size and shape of the nucleus via mechanical forces transmitted through the cytoskeleton. However, the effects of these biophysical stimuli on internal nuclear architecture and cellular… read more here.
Keywords: structure function; extracellular adhesive; nucleolar structure; adhesive cues ... See more keywords
Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800801
Abstract: Antimicrobial peptides (AMPs) kill bacteria by targeting their membranes through various mechanisms involving peptide assembly, often coupled with disorder‐to‐order structural transition. However, for several AMPs, similar conformational changes in cases in which small organic compounds… read more here.
Keywords: peptide; drug; cm15; function ... See more keywords
SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition
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DOI: 10.1002/cbic.202200327
Abstract: Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline the importance of investigating various viral proteins as potential drug targets. The papain‐like protease of coronaviruses has been less explored than other viral proteins; however,… read more here.
Keywords: like protease; papain like; structure function; sars cov ... See more keywords
Effect of UV Stress on the Structure and Function of Pro‐apoptotic Bid and Anti‐apoptotic Bcl‐xl proteins
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200682
Abstract: Ultraviolet C (UV‐C) radiation induces apoptosis in mammalian cells via the mitochondrion‐mediated pathway. The Bcl‐2 family of proteins are the regulators of the mitochondrial pathway of apoptosis and appears responsive to UV‐C radiation. It is… read more here.
Keywords: pro apoptotic; structure function; function pro; bid ... See more keywords
Structure and Function of Na,K-ATPase-The Sodium-Potassium Pump.
Sign Up to like & getrecommendations! Published in 2021 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c200018
Abstract: Na,K-ATPase is an ubiquitous enzyme actively transporting Na-ions out of the cell in exchange for K-ions, thereby maintaining their concentration gradients across the cell membrane. Since its discovery more than six decades ago the Na-pump… read more here.
Keywords: function atpase; atpase sodium; structure function; atpase ... See more keywords
Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12687
Abstract: Heart failure (HF) incidence increases markedly with age. We examined age‐associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community‐based cohort aged ≥60… read more here.
Keywords: longitudinal change; risk; change cardiac; cardiac structure ... See more keywords
Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13283
Abstract: This study aimed to examine if the cardiac changes associated with uraemic cardiomyopathy are reversed by renal transplantation. read more here.
Keywords: structure function; renal transplantation; changes left; ventricular structure ... See more keywords
Blood pressure trajectories in early adulthood and myocardial structure and function in later life
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13803
Abstract: This study sought to investigate the association between blood pressure (BP) trajectories from early to middle adulthood and echocardiographic indices of structure and function in middle age. read more here.
Keywords: trajectories early; structure function; blood pressure; pressure trajectories ... See more keywords
Effect of Vericiguat on Left Ventricular Structure and Function in Patients with Heart Failure with Reduced Ejection Fraction: The VICTORIA Echocardiographic Substudy.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of heart failure"
DOI: 10.1002/ejhf.2836
Abstract: BACKGROUND Vericiguat significantly reduced the primary composite outcome of heart failure (HF) hospitalization or cardiovascular death in the VICTORIA trial. It is unknown if these outcome benefits are related to reverse left ventricular (LV) remodeling… read more here.
Keywords: structure function; ejection fraction; heart failure; vericiguat ... See more keywords