The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200274
Abstract: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial 1‐carbon metabolism enzyme, which is an attractive anticancer drug target as it is highly upregulated in cancer but is not expressed in healthy adult cells. Selective MTHFD2 inhibitors… read more here.
Keywords: mthfd2l; isoform selective; structure; structure human ... See more keywords
Structure of human BCCIP and implications for binding and modification of partner proteins
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4026
Abstract: BCCIP was isolated based on its interactions with tumor suppressors BRCA2 and p21. Knockdown or knockout of BCCIP causes embryonic lethality in mice. BCCIP deficient cells exhibit impaired cell proliferation and chromosome instability. BCCIP also… read more here.
Keywords: bccip; human bccip; partner proteins; structure human ... See more keywords
On the quaternary structure of human D‐3‐phosphoglycerate dehydrogenase
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.5089
Abstract: D‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in L‐Ser metabolism… read more here.
Keywords: structure human; phosphoglycerate dehydrogenase; dehydrogenase; quaternary structure ... See more keywords
Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.007
Abstract: Human ATP-binding cassette transporter 8 of subfamily B (hABCB8) is an ABC transporter that located in the inner membrane of mitochondria. The ABCB8 is involved in the maturation of Fe-S and protects the heart from… read more here.
Keywords: structure human; cryo structure; human abcb8; transporter ... See more keywords
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107837
Abstract: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases. One of the least understood components of the autophagy… read more here.
Keywords: autophagy machinery; structure; structure human; human atg9a ... See more keywords
Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.03.029
Abstract: Ribonuclease P (RNase P) catalyzes the removal of 5' leaders of tRNA precursors and its central catalytic RNA subunit is highly conserved across all domains of life. In eukaryotes, RNase P and RNase MRP, a… read more here.
Keywords: crystal structure; rpp20 rpp25; rpp20; human rpp20 ... See more keywords
The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c06971
Abstract: Physiologically relevant in vitro models of amyloid aggregation are essential for linking structural insights to disease pathology. In type 2 diabetes, aggregation of human islet amyloid polypeptide (hIAPP) into fibrils is a hallmark of β-cell… read more here.
Keywords: human iapp; hiapp fibrils; hiapp; structure ... See more keywords
Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2357
Abstract: O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displays three… read more here.
Keywords: crystal structure; activity inhibition; inhibition crystal; structure human ... See more keywords
The structure of human thyroglobulin
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1995-4
Abstract: Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates 1 , 2 . Hormone synthesis from TG occurs in the thyroid gland… read more here.
Keywords: microscopy; human thyroglobulin; thyroid hormones; structure ... See more keywords
Structure of the human dopamine transporter and mechanisms of inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07739-9
Abstract: The neurotransmitter dopamine has central roles in mood, appetite, arousal and movement1. Despite its importance in brain physiology and function, and as a target for illicit and therapeutic drugs, the human dopamine transporter (hDAT) and… read more here.
Keywords: human dopamine; dopamine transporter; structure human; transporter ... See more keywords
Structure of the human cation–chloride cotransport KCC1 in an outward-open state
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109083119
Abstract: Significance Cation–chloride cotransporters (CCCs) shuttle Na+, K+, and Cl− across membranes. However, it remains unclear how CCCs alternate between transport states so they can load ions from one side of a membrane for release into… read more here.
Keywords: structure human; human cation; cation; cation chloride ... See more keywords