Structure and inhibition of the human lysosomal transporter Sialin
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48535-3
Abstract: Sialin, a member of the solute carrier 17 (SLC17) transporter family, is unique in its ability to transport not only sialic acid using a pH-driven mechanism, but also transport mono and diacidic neurotransmitters, such as… read more here.
Keywords: human lysosomal; sialic acid; structure inhibition; transporter ... See more keywords
Structure and Inhibition of the Human Na+/H+ Exchanger SLC9B2
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26094221
Abstract: The sodium/proton exchanger NHA2, also known as SLC9B2, is important for insulin secretion, renal blood pressure regulation, and electrolyte retention. Recent structures of bison NHA2 has revealed its unique 14-transmembrane helix architecture, which is different… read more here.
Keywords: human nha2; structure; exchanger; slc9b2 ... See more keywords