Next generation protein structure predictions and genetic variant interpretation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167180
Abstract: The need to make sense of the thousands of genetic variants uncovered every day in terms of pathology or biological mechanism is acute. Many insights into how genetic changes impact protein function can be gleaned… read more here.
Keywords: protein; structure predictions; structure; next generation ... See more keywords
A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54668-2
Abstract: Structure predictions have become invaluable tools, but viral proteins are absent from the EMBL/DeepMind AlphaFold database. Here, we provide proteome-wide structure predictions for all nine human herpesviruses and analyze them in depth with explicit scoring… read more here.
Keywords: protein families; proteome wide; structure predictions; wide structural ... See more keywords
Digging into the 3D Structure Predictions of AlphaFold2 with Low Confidence: Disorder and Beyond
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101467
Abstract: AlphaFold2 (AF2) has created a breakthrough in biology by providing three-dimensional structure models for whole-proteome sequences, with unprecedented levels of accuracy. In addition, the AF2 pLDDT score, related to the model confidence, has been shown… read more here.
Keywords: structure; confidence; structure predictions; predictions alphafold2 ... See more keywords
“It’s Only a Model”: When Protein Structure Predictions Need Experimental Validation, the Case of the HTLV-1 Tax Protein
Sign Up to like & getrecommendations! Published in 2024 at "Pathogens"
DOI: 10.3390/pathogens13030241
Abstract: Human T-cell Leukemia Virus type 1 (HTLV-1) is a human retrovirus responsible for leukaemia in 5 to 10% of infected individuals. Among the viral proteins, Tax has been described as directly involved in virus-induced leukemogenesis.… read more here.
Keywords: structure; tax; structure predictions; protein structure ... See more keywords