The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14369
Abstract: Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this… read more here.
Keywords: aggregation; toxicity; structure toxicity; unsaturation fatty ... See more keywords
A detailed structural study of cytotoxicity effect of ionic liquids on the leukemia rat cell line IPC-81 by three dimensional quantitative structure toxicity relationship.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.04.040
Abstract: In the present study, a very thorough and in-depth three-dimensional quantitative structure-toxicity relationship (3D-QSTR) analysis has been implemented to make a correlation between the structural information of the ionic liquids (ILs) and their cytotoxicity towards… read more here.
Keywords: three dimensional; quantitative structure; structure toxicity; toxicity relationship ... See more keywords
Structure‐toxicity relationship of cefoperazone and its impurities to developing zebrafish by transcriptome and Raman analysis
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.04.025
Abstract: ABSTRACT Cefoperazone (CFP) is a potent antibacterial agent that is widely used for the treatment of bacterial infections. Previously, we found that both the C‐7 and C‐3 substituents of CFP are toxic functional groups, and… read more here.
Keywords: cefoperazone; analysis; structure toxicity; cfp ... See more keywords
Elucidation of the Effect of Phospholipid Charge on the Rate of Insulin Aggregation and Structure and Toxicity of Amyloid Fibrils
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00159
Abstract: The plasma membrane is a dynamic structure that separates the cell interior from the extracellular space. The fluidity and plasticity of the membrane determines a large number of physiologically important processes ranging from cell division… read more here.
Keywords: insulin aggregation; structure toxicity; charge; structure ... See more keywords
Insights into structure, toxicity and antibacterial potential of tungsten oxide–carbon nanocomposites coupled with antibiotics
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-23257-8
Abstract: The Houbara bustard is a vulnerable bird species that often experiences higher morbidity and mortality due to infections caused by the multiple drug-resistant pathogens like Salmonella. Studies exploring alternative therapeutics are essential to strengthen antimicrobial… read more here.
Keywords: antibacterial potential; wnc; insights structure; toxicity ... See more keywords
Development of reliable quantitative structure–toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2118092
Abstract: Abstract The Health and environmental hazards of benzene and nitrobenzene (NB) derivatives have remained a topic of interest of researchers. In silico methods for prediction of toxicity of chemicals have proved their worth in accurate… read more here.
Keywords: quantitative structure; toxicity; toxicity relationship; benzene derivatives ... See more keywords
Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020477
Abstract: Isoquinoline alkaloids constitute one of the most common classes of alkaloids that have shown a pronounced role in curing various diseases. Finding ways to reduce the toxicity of these molecules and to increase their therapeutic… read more here.
Keywords: toxicity structure; series; toxicity; acute toxicity ... See more keywords
Quantitative Structure–Toxicity Relationship in Bioactive Molecules from a Conceptual DFT Perspective
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111383
Abstract: The preclinical drug discovery stage often requires a large amount of costly and time-consuming experiments using huge sets of chemical compounds. In the last few decades, this process has undergone significant improvements by the introduction… read more here.
Keywords: structure toxicity; toxicity relationship; quantitative structure; structure ... See more keywords
Theoretical Studies on the Quantitative Structure–Toxicity Relationship of Polychlorinated Biphenyl Congeners Reveal High Affinity Binding to Multiple Human Nuclear Receptors
Sign Up to like & getrecommendations! Published in 2024 at "Toxics"
DOI: 10.3390/toxics12010049
Abstract: Polychlorinated biphenyls (PCBs) are organic chemicals consisting of a biphenyl structure substituted with one to ten chlorine atoms, with 209 congeners depending on the number and position of the chlorine atoms. PCBs are widely known… read more here.
Keywords: toxicity relationship; structure; nuclear receptors; structure toxicity ... See more keywords