Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors.
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DOI: 10.1021/acschembio.2c00177
Abstract: The main challenge in inhibiting protein-protein interactions (PPI) for therapeutic purposes is designing molecules that bind specifically to the interaction hotspots. Adding to the complexity, such hotspots can be within both structured and disordered interaction… read more here.
Keywords: interaction; structured disordered; interaction hotspots; peptide inhibitors ... See more keywords