Protocol to Generate Ureteric Bud Structures from Human iPS Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9021-4_10
Abstract: The generation of ureteric bud (UB), which is the renal progenitor that gives rise to renal collecting ducts and lower urinary tract, from human-induced pluripotent stem cells (hiPSCs) provides a cell source for studying the… read more here.
Keywords: generate ureteric; human ips; ureteric bud; structures human ... See more keywords
Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.009
Abstract: The signaling of prostaglandin D2 (PGD2) through G-protein-coupled receptor (GPCR) CRTH2 is a major pathway in type 2 inflammation. Compelling evidence suggests the therapeutic benefits of blocking CRTH2 signaling in many inflammatory disorders. Currently, a… read more here.
Keywords: crth2; recognition; structures human; reveal ... See more keywords
Complete chemical structures of human mitochondrial tRNAs
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18068-6
Abstract: Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are… read more here.
Keywords: mitochondrial trnas; human mitochondrial; trna modifications; chemical structures ... See more keywords
Smuggling and Sovereignty: Individual Agencies within the Structures of Human Smuggling and Enforcement in the Mediterranean
Sign Up to like & getrecommendations! Published in 2019 at "Geopolitics"
DOI: 10.1080/14650045.2019.1665780
Abstract: Coverage of ‘Borderland Schengen’ and the European immigration ‘crisis’ continues to produce ‘irregular’ migrants through visual-political processes not only as threats to stability and cohesion in... read more here.
Keywords: sovereignty individual; individual agencies; agencies within; within structures ... See more keywords
Ligamentous structures in human glans penis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Anatomy"
DOI: 10.1111/joa.12896
Abstract: The corpus spongiosum reportedly occupies a larger proportion of the human glans penis than does the penile body, embedding the end of the corpus cavernosus (CC). However, anatomic descriptions about the fibrous structures of glans… read more here.
Keywords: ligamentous structures; anatomy; glans penis; structures human ... See more keywords
Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add9742
Abstract: Secretory pathway Ca2+/Mn2+ ATPase 1 (SPCA1) actively transports cytosolic Ca2+ and Mn2+ into the Golgi lumen, playing a crucial role in cellular calcium and manganese homeostasis. Detrimental mutations of the ATP2C1 gene encoding SPCA1 cause… read more here.
Keywords: ca2 mn2; mn2 transport; structures human; human spca1a ... See more keywords
Novel hemodynamic structures in the human glomerulus
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Physiology - Renal Physiology"
DOI: 10.1152/ajprenal.00566.2017
Abstract: To investigate human glomerular structure under conditions of physiological perfusion, we have analyzed fresh and perfusion-fixed normal human glomeruli at physiological hydrostatic and oncotic pressures using serial resin section reconstruction, confocal, multiphoton, and electron microscope… read more here.
Keywords: hemodynamic structures; conduit vessels; physiology; structures human ... See more keywords
Cryo-EM structures of human coagulation factors V and Va.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2021010684
Abstract: Coagulation factor V is the precursor of factor Va that, together with factor Xa, Ca2+ and phospholipids, defines the prothrombinase complex and activates prothrombin in the penultimate step of the coagulation cascade. Here we present… read more here.
Keywords: coagulation; factor; structures human; cryo structures ... See more keywords
Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures.
Sign Up to like & getrecommendations! Published in 2020 at "PLOS Biology"
DOI: 10.2210/pdb6kwy/pdb
Abstract: Proteasomes are highly abundant and conserved protease complexes that eliminate unwanted proteins in the cells. As a single-chain ATP-independent nuclear proteasome activator, proteasome activator 200 (PA200) associates with 20S core particle to form proteasome complex… read more here.
Keywords: pa200 20s; proteasome; cryo structures; pa200 ... See more keywords
Structures of Human Transglutaminase 2: Finding Clues for Interference in Cross-linking Mediated Activity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21062225
Abstract: Human transglutaminase 2 (TGase2) has various functions, including roles in various cellular processes such as apoptosis, development, differentiation, wound healing, and angiogenesis, and is linked to many diseases such as cancer. Although TGase2 has been… read more here.
Keywords: transglutaminase; tgase2; human transglutaminase; structures human ... See more keywords