Mono-PEGylates of Exenatide in Branched and Dimeric Structures Can Improve In vivo Stability and Hypoglycemic Bioactivity.
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DOI: 10.1016/j.jbiotec.2019.09.016
Abstract: Exenatide, a synthetic version of exendin-4, is a glucagon-like peptide-1 receptor agonist (GLP-1RA) used for treating diabetes, but its relatively short half-life is a major disadvantage. In this study, we attempted residue-specific mono-PEGylation to the… read more here.
Keywords: improve vivo; shape; mono pegylates; mono ... See more keywords