Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
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DOI: 10.1016/j.jsb.2018.04.001
Abstract: Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of… read more here.
Keywords: polyketide; structures ketoreductase; bound structures; substrate bound ... See more keywords