Cryo-EM structures reveal distinct apo conformations of sortilin-related receptor SORLA.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.108
Abstract: Sorting-related receptor with A-type repeats (SORLA) is an important receptor for regulating normal cellular functions via protein sorting. Here, we determined the structures of the full-length SORLA and identified two distinct conformations of apo-SORLA using… read more here.
Keywords: reveal distinct; distinct apo; structures reveal; cryo structures ... See more keywords
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.017
Abstract: P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The P2X7 receptor subtype is a pharmacological target because of involvement in apoptotic, inflammatory, and tumor progression pathways. It is the most structurally and… read more here.
Keywords: full length; p2x7; structures reveal; receptor ... See more keywords
Structures reveal opening of the store-operated calcium channel Orai
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.36758
Abstract: The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER).… read more here.
Keywords: store operated; structures reveal; orai; operated calcium ... See more keywords
Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.77469
Abstract: RFC uses ATP to assemble PCNA onto primed sites for replicative DNA polymerases δ and ε. The RFC pentamer forms a central chamber that binds 3′ ss/ds DNA junctions to load PCNA onto DNA during… read more here.
Keywords: dna; rfc; structures reveal; gap ... See more keywords