Cryo-EM structures reveal distinct apo conformations of sortilin-related receptor SORLA.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.108
Abstract: Sorting-related receptor with A-type repeats (SORLA) is an important receptor for regulating normal cellular functions via protein sorting. Here, we determined the structures of the full-length SORLA and identified two distinct conformations of apo-SORLA using… read more here.
Keywords: reveal distinct; distinct apo; structures reveal; cryo structures ... See more keywords
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.017
Abstract: P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The P2X7 receptor subtype is a pharmacological target because of involvement in apoptotic, inflammatory, and tumor progression pathways. It is the most structurally and… read more here.
Keywords: full length; p2x7; structures reveal; receptor ... See more keywords
CryoEM structures reveal how the bacterial flagellum rotates and switches direction
Sign Up to like & getrecommendations! Published in 2024 at "Nature Microbiology"
DOI: 10.1038/s41564-024-01674-1
Abstract: Bacterial chemotaxis requires bidirectional flagellar rotation at different rates. Rotation is driven by a flagellar motor, which is a supercomplex containing multiple rings. Architectural uncertainty regarding the cytoplasmic C-ring, or ‘switch’, limits our understanding of… read more here.
Keywords: direction; reveal bacterial; cryoem; structures reveal ... See more keywords
Cryo-EM structures reveal the acetylation process of piccolo NuA4
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2414490122
Abstract: Significance Histone acetylation is one of the most important epigenetic modifications that can induce structural changes in chromatin and regulate gene transcription. NuA4 is the only essential acetyltransferase in yeast that can catalyze the acetylation… read more here.
Keywords: reveal acetylation; cryo structures; acetylation process; acetylation ... See more keywords
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-024-01806-y
Abstract: Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk of developing progressive… read more here.
Keywords: alzheimer disease; alzheimer; cryo structures; tau ... See more keywords
Cryo-EM structures reveal the H+/citrate symport mechanism of Drosophila INDY
Sign Up to like & getrecommendations! Published in 2025 at "Life Science Alliance"
DOI: 10.26508/lsa.202402992
Abstract: We provide cryo-EM structures of Drosophila INDY in diverse functional states at near-atomic resolution. Our structures reveal its conformational cycle, sodium-independent H+/citrate co-transport, and phospholipid effects on stability. These findings provide molecular insights into the… read more here.
Keywords: reveal citrate; cryo structures; cryo; drosophila indy ... See more keywords
Structures reveal opening of the store-operated calcium channel Orai
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.36758
Abstract: The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER).… read more here.
Keywords: store operated; structures reveal; orai; operated calcium ... See more keywords
Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.77469
Abstract: RFC uses ATP to assemble PCNA onto primed sites for replicative DNA polymerases δ and ε. The RFC pentamer forms a central chamber that binds 3′ ss/ds DNA junctions to load PCNA onto DNA during… read more here.
Keywords: dna; rfc; structures reveal; gap ... See more keywords