Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13110
Abstract: The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like spreading of protein inclusions in a number of human… read more here.
Keywords: synuclein filaments; seeded assembly; structures synuclein; system atrophy ... See more keywords
Alternative Structures of α-Synuclein
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DOI: 10.3390/molecules25030600
Abstract: The object of our analysis is the structure of alpha-synuclein (ASyn), which, under in vivo conditions, associates with presynaptic vesicles. Misfolding of ASyn is known to be implicated in Parkinson’s disease. The availability of structural… read more here.
Keywords: structures synuclein; asyn; analysis; structure ... See more keywords