Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.07.011
Abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the hallmarks of AD. Several lines of evidence have shown a… read more here.
Keywords: aggregation; mechanism; amyloid peptides; structural studies ... See more keywords
Single-molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Quarterly Reviews of Biophysics"
DOI: 10.1017/s0033583520000086
Abstract: Abstract In neurodegenerative diseases, a wide range of amyloid proteins or peptides such as amyloid-beta and α-synuclein fail to keep native functional conformations, followed by misfolding and self-assembling into a diverse array of aggregates. The… read more here.
Keywords: single molecule; amyloid proteins; studies amyloid; proteins biophysical ... See more keywords