Genome‐wide interaction studies identify sex‐specific risk alleles for nonsyndromic orofacial clefts
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22158
Abstract: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial birth defect in humans and is notable for its apparent sexual dimorphism where approximately twice as many males are affected as… read more here.
Keywords: genome wide; risk; sex; studies identify ... See more keywords
Computational studies to identify the common type‐I and type‐II inhibitors against the CDK8 enzyme
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30209
Abstract: In this study, multicomplex‐based pharmacophore modeling was conducted on the structural proteome of the two states of CDK8 protein, that is, DMG‐in and out. Three pharmacophores having six, five, and four features were selected as… read more here.
Keywords: common type; studies identify; type type; identify common ... See more keywords
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2458
Abstract: Enhancing production of the anti-inflammatory cytokine interleukin-10 (IL-10) is a promising strategy to suppress pathogenic inflammation. To identify new mechanisms regulating IL-10 production, we conducted a phenotypic screen for small molecules that enhance IL-10 secretion… read more here.
Keywords: identify cdk8; small molecule; cdk8 cdk19; cdk8 ... See more keywords
Longitudinal studies can identify distinct inflammatory cytokines associated with the inhibition or progression of liver cancer
Sign Up to like & getrecommendations! Published in 2019 at "Liver International"
DOI: 10.1111/liv.14323
Abstract: Chronic diseases such as nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) are associated with chronic inflammation. However, controversial reports as to the key cytokines involved in the process of chronic inflammation hinder development… read more here.
Keywords: longitudinal studies; inflammatory cytokines; identify distinct; progression liver ... See more keywords