Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis
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DOI: 10.1002/cmdc.201800238
Abstract: Schistosomiasis is a neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy relies on mass treatment with only one drug: praziquantel. Based on the 3‐chlorobenzothiophene‐2‐hydroxamic acid J1075,… read more here.
Keywords: schistosomiasis; treatment; crystallization studies; studies vitro ... See more keywords
Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent
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DOI: 10.1016/j.molstruc.2016.12.056
Abstract: Abstract The present article describes the synthesis and biological studies in vitro of a novel silver complex with furosemide (Ag-FSE). Elemental, thermal and mass spectrometric analysis indicated a 1:1 metal/ligand composition, with the molecular formula AgC… read more here.
Keywords: silver complex; fse; biological studies; complex furosemide ... See more keywords
Molecular docking, Synthesis, Computational Studies and In-vitro evaluation of 7-Substituted-2-Pyrimidinyl Chromen-4-one derivatives
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DOI: 10.52711/0974-360x.2023.00181
Abstract: Design and synthesis of 7-substituted-2-pyrimidinyl chromen-4-one derivatives as selective Cyclooxygenase-2 inhibitors (1) Method: The compounds were designed using molecular hybridization technique, docking studies was performed using Autodock Vina, compounds having higher affinity than celecoxib were… read more here.
Keywords: pyrimidinyl chromen; studies vitro; chromen one; substituted pyrimidinyl ... See more keywords