Synthesis, computational study and cytotoxicity of 4-hydroxycoumarin-derived imines/enamines
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DOI: 10.1007/s11030-020-10086-2
Abstract: Abstract In this study, we applied a direct condensation between 3-acetyl-4-hydroxy-2 H -chromen-2-one and different amines (anilines and benzyl amines) in order to synthesize some coumarin-based imines/enamines ( 3a – o ) as cytotoxic agents.… read more here.
Keywords: imines enamines; study cytotoxicity; computational study; study ... See more keywords
Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety
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DOI: 10.3390/molecules27196368
Abstract: Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylthiourea (2) was prepared and reacted with… read more here.
Keywords: molecular docking; docking study; thiadiazole; thiazole derivatives ... See more keywords