Edaravone administration in pivotal clinical Study 19
Sign Up to like & getrecommendations! Published in 2019 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2019.1582672
Abstract: Recently, ALSFTD published an editorial entitled “Is edaravone harmful? (A placebo is not a control)” (1). The editorial questioned whether the mode of administration of study drug in pivotal Study 19 affected the disease trajectory… read more here.
Keywords: administration; study; decline; study drug ... See more keywords
The Second of Two One-Year, Multicenter, Open-Label, Repeat-Dose, Phase II Safety Studies of PrabotulinumtoxinA for the Treatment of Moderate to Severe Glabellar Lines in Adult Patients.
Sign Up to like & getrecommendations! Published in 2021 at "Aesthetic surgery journal"
DOI: 10.1093/asj/sjaa382
Abstract: BACKGROUND PrabotulinumtoxinA is a 900-kDa botulinum toxin type A produced by Clostridium botulinum. OBJECTIVES The authors sought to investigate the safety of prabotulinumtoxinA for treatment of glabellar lines. METHODS This was a multicenter, open-label, repeat-dose,… read more here.
Keywords: severe glabellar; treatment; safety; study drug ... See more keywords
The First of Two One-Year, Multicenter, Open-Label, Repeat-Dose, Phase II Safety Studies of PrabotulinumtoxinA for the Treatment of Moderate to Severe Glabellar Lines in Adult Patients.
Sign Up to like & getrecommendations! Published in 2021 at "Aesthetic surgery journal"
DOI: 10.1093/asj/sjaa383
Abstract: BACKGROUND PrabotulinumtoxinA is a 900-kDa botulinum toxin type A produced by Clostridium botulinum. OBJECTIVES The authors sought to investigate the safety of prabotulinumtoxinA for treatment of glabellar lines. METHODS This was a multicenter, open-label, repeat-dose,… read more here.
Keywords: severe glabellar; treatment; safety; study drug ... See more keywords
Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug–drug interactions with different perpetrator drugs
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14277
Abstract: Using 3 different perpetrators the impact of voriconazole, cobicistat and rifampicin (single dose), we evaluated the suitability of a microdose cocktail of factor Xa inhibitors (FXaI; rivaroxaban, apixaban and edoxaban; 100 μg in total) to… read more here.
Keywords: factor inhibitors; drug interactions; drug; study drug ... See more keywords
A study of the drug tildrakizumab for plaque psoriasis
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.19075
Abstract: Tildrakizumab is a fairly new type of medicine called a biologic, used for the treatment of moderate‐to‐severe psoriasis. The drug prevents the action of a specific molecule in the body involved in inflammation, known as… read more here.
Keywords: drug tildrakizumab; drug; study drug; tildrakizumab plaque ... See more keywords
Understanding Study Drug Discontinuation Through EUCLID
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.947645
Abstract: Introduction Disparities in the care and outcomes of peripheral artery disease (PAD) have been well-established. In part this is due to disparities in enrollment of PAD trial cohorts. However, less attention has been paid to… read more here.
Keywords: drug; study drug; drug discontinuation; understanding study ... See more keywords