Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210114119
Abstract: American bullfrog (Rana castesbeiana) saxiphilin (RcSxph) is a high-affinity ‘toxin sponge’ protein thought to prevent intoxication by saxitoxin (STX), a lethal bis-guanidinium neurotoxin that causes paralytic shellfish poisoning (PSP) by blocking voltage-gated sodium channels (NaVs).… read more here.
Keywords: saxitoxin stx; stx binding; stx; binding code ... See more keywords
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins
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DOI: 10.1126/sciadv.aax2650
Abstract: Bullfrog saxiphilin:STX complex defines a toxin “molecular sponge” blueprint for STX recognition and toxin resistance. Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble… read more here.
Keywords: stx binding; recognition; molecular recognition; stx ... See more keywords
Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity
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DOI: 10.3390/toxins13020139
Abstract: Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic–uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC). The characterization of the major and minor Stx-binding… read more here.
Keywords: epithelial cells; stx binding; binding glycosphingolipids; shiga toxin ... See more keywords