STX2 is a causative gene for nonobstructive azoospermia
Sign Up to like & getrecommendations! Published in 2018 at "Human Mutation"
DOI: 10.1002/humu.23423
Abstract: STX2 encodes a sulfoglycolipid transporter. Although Stx2 nullizygosity is known to cause spermatogenic failure in mice, STX2 mutations have not been identified in humans. Here, we performed STX2 mutation analysis for 131 Japanese men clinically… read more here.
Keywords: nonobstructive azoospermia; stx2 causative; stx2; mutation ... See more keywords
STX2 drives colorectal cancer proliferation via upregulation of EXOSC4.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118597
Abstract: AIMS To explore the biological function and mechanism of Syntaxin2 (STX2) in Colorectal cancer (CRC) proliferation. MAIN METHODS A series of gain- and loss-of-function analysis were conducted to explore the biological function of STX2 in… read more here.
Keywords: proliferation via; crc proliferation; colorectal cancer; proliferation ... See more keywords
LPS-primed CD11b+ leukocytes serve as an effective carrier of Shiga toxin 2 to cause hemolytic uremic syndrome in mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22327-4
Abstract: Shiga toxin (Stx)-induced hemolytic uremic syndrome (HUS) is a life-threatening complication associated with Stx-producing Escherichia coli infection. One critical barrier of understanding HUS is how Stx transports from infected intestine to kidney to cause HUS.… read more here.
Keywords: cause; hemolytic uremic; carrier; toxin ... See more keywords
The effect of two ribonucleases on the production of Shiga toxin and stx-bearing bacteriophages in Enterohaemorrhagic Escherichia coli
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DOI: 10.1038/s41598-021-97736-z
Abstract: Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of intestinal pathogens responsible for a range of illnesses, including kidney failure and neurological compromise. EHEC produce critical virulence factors, Shiga toxin (Stx) 1 or 2, and the… read more here.
Keywords: production; enterohaemorrhagic escherichia; escherichia coli; toxin ... See more keywords
Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc06299k
Abstract: Using amphiphilic cyclodextrin as a scaffold, the first class of PK-glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported. The generated glycomicroarray effectively mimics the plasma… read more here.
Keywords: clustering trisaccharides; stx2; amphiphilic cyclodextrin; unprecedented affinity ... See more keywords
Characterization of Atypical Shiga Toxin Gene Sequences and Description of Stx2j, a New Subtype
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.02229-21
Abstract: Shiga toxin (Stx) is the definitive virulence factor of Shiga toxin-producing Escherichia coli (STEC). Stx variants are currently organized into a taxonomic system of three Stx1 (a, c, and d) and seven Stx2 (a, b,… read more here.
Keywords: toxin; stx2; characterization atypical; subtype ... See more keywords
Investigation on the Evolution of Shiga Toxin-Converting Phages Based on Whole Genome Sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.01472
Abstract: Bacteriophages are pivotal elements in the dissemination of virulence genes. The main virulence determinants of Shiga Toxin producing E. coli, Shiga Toxins (Stx), are encoded by genes localized in the genome of lambdoid bacteriophages. Stx… read more here.
Keywords: stx2; converting phages; evolution; shiga toxin ... See more keywords
Role of Shiga Toxins in Cytotoxicity and Immunomodulatory Effects of Escherichia coli O157:H7 during Host-Bacterial Interactions in vitro
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DOI: 10.3390/toxins12010048
Abstract: Enterohemorrhagic Escherichia coli (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or 2c (Stx2)-producing E. coli O157:H7 is the serotype most frequently associated with severe human disease. In this… read more here.
Keywords: escherichia coli; coli o157; host; stx2 ... See more keywords
Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14020069
Abstract: Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown. We determined Stx receptor Gb3 in murine… read more here.
Keywords: circadian rhythm; proximal tubular; expression; stx2 ... See more keywords