Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes
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DOI: 10.1002/jcp.25939
Abstract: Diabetes is considered a major public health problem affecting millions of individuals worldwide. Remarkably, scientific reports regarding salivary glands sphingolipid metabolism in diabetes are virtually non‐existent. This is odd given the well‐established link between the… read more here.
Keywords: metabolism salivary; metabolism; stz; sphingolipids metabolism ... See more keywords
Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11
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DOI: 10.1007/s00335-018-9742-y
Abstract: Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported; however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the… read more here.
Keywords: susceptibility; stz; diabetes susceptibility; induced diabetes ... See more keywords
The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells
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DOI: 10.1007/s11064-021-03269-2
Abstract: Recently neuronal insulin resistance was suggested playing a role in Alzheimer’s disease. Streptozotocin (STZ) is commonly used to induce impairment in insulin metabolism. In our previous work on undifferentiated SH-SY5Y cells the compound exerted cytotoxicity… read more here.
Keywords: insulin; stz; sensitivity; differentiation ... See more keywords
Potential therapeutic role of melatonin on STZ-induced diabetic central neuropathy: A biochemical, histopathological, immunohistochemical and ultrastructural study.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2018.09.008
Abstract: The aim of the present study was to assess the therapeutic potential of melatonin (Mel) in diabetic central neuropathy in a rat model of streptozotocin (STZ)-induced diabetes. The rats were injected with 60 mg/kg STZ and… read more here.
Keywords: stz induced; stz; induced diabetic; diabetic central ... See more keywords
Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.054
Abstract: BACKGROUND Neurodegenerative disorders, such as deficits in learning, memory and cognition and Alzheimer's disease are associated with diabetes mellitus. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor and is known to possess anti-obesity, anti-diabetic actions… read more here.
Keywords: stz; diabetes mellitus; rin5f cells; rin5f ... See more keywords
Selenothymidine protects against biochemical and behavioral alterations induced by ICV-STZ model of dementia in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.08.004
Abstract: The present study evaluated the neuroprotective effects of one selenium-containing AZT derivative compound (S1073) in memory and learning impairment caused by Intracerebroventricular-streptozotocin (ICV-STZ). ICV-STZ in mice causes impairment of energy metabolism with oxidative damage and… read more here.
Keywords: dementia; icv stz; stz; model ... See more keywords
Streptozocin; a GLUT2 binding drug, interacts with human serum albumin at loci h6DOM3-h7DOM3.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.01.217
Abstract: Streptozocin (STZ) is a broad range antibiotic, highly genotoxic, antineoplastic and hyperglycemic. HSA is the most abundant protein in physiology and it binds to almost all exogenic and endogenic ligands, including drugs. STZ-induced fluorescence quenching… read more here.
Keywords: h6dom3 h7dom3; stz; drug; hsa ... See more keywords
Alleviative effects of 20(R)-Rg3 on HFD/STZ-induced diabetic nephropathy via MAPK/NF-κB signaling pathways in C57BL/6 mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113500
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Diabetic nephropathy (DN) is a major complication of diabetes. The kidney disease develops in nearly 20%∼40 % of type 2 diabetes (T2D) patients. Ginseng is the root of Panax ginseng C. A. Meyer… read more here.
Keywords: hfd stz; stz; diabetic nephropathy; alleviative effects ... See more keywords
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
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DOI: 10.1016/j.lfs.2019.05.046
Abstract: AIMS The evidence suggests that the hyperglycemia and hyperinsulinemia of diabetes mellitus (DM) are risk factors for the development of hepatocellular carcinoma (HCC). The aim of the present study was to examine the effect of… read more here.
Keywords: hepatocellular carcinoma; hcc; stz; den ... See more keywords
The ameliorative effect of bromelain on STZ-induced type 1 diabetes in rats through Oxi-LDL/LPA/LPAR1 pathway.
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DOI: 10.1016/j.lfs.2021.119982
Abstract: AIMS Diabetes, a serious worldwide problem, is modulated via inflammation and oxidative stress. Bromelain, a natural compound, recently attracts interest due to its anti-inflammatory effects, while its mode of action remains not properly understood. Thus,… read more here.
Keywords: oxi ldl; stz; effect bromelain; ldl lpa ... See more keywords
Impairment of renal steroidogenesis at the onset of diabetes
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DOI: 10.1016/j.mce.2021.111170
Abstract: Accumulating evidence indicates the association between changes in circulating sex steroid hormone levels and the development of diabetic nephropathy. However, the renal synthesis of steroid hormones during diabetes is essentially unknown. Male Wistar rats were… read more here.
Keywords: steroidogenesis onset; stz; onset diabetes; impairment renal ... See more keywords