Inhibition of BMP4 alleviates diabetic retinal vascular dysfunction via the VEGF and smad1/5 signalling.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2023.2190054
Abstract: Objective:The aim of our study was to determine the molecular mechanism of BMP4 (bone morphogenetic protein 4) in DR (diabetic retinopathy).Methods: Human retinal endothelial cell (HRECs) induced by high glucose to simulate one of the… read more here.
Keywords: vegf; diabetic retinopathy; bmp4 could; inhibition bmp4 ... See more keywords
Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Epigenetics"
DOI: 10.1186/s13148-023-01620-8
Abstract: Background The objective of this study was to examine and analyze differential methylation profiles in order to investigate the influence of hyper-methioninemia (HM) on the development of diabetic nephropathy (DN). Male Wistar rats, aged eight… read more here.
Keywords: methylation; tangshen formula; group; stz group ... See more keywords
Severe Hypoglycemia–Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia
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DOI: 10.2337/db17-0306
Abstract: We previously demonstrated that insulin-mediated severe hypoglycemia induces lethal cardiac arrhythmias. However, whether chronic diabetes and insulin deficiency exacerbates, and whether recurrent antecedent hypoglycemia ameliorates, susceptibility to arrhythmias remains unknown. Thus, adult Sprague-Dawley rats were… read more here.
Keywords: hypoglycemia; group; arrhythmias; severe hypoglycemia ... See more keywords