Antidiabetic and neuroprotective effects of a novel repaglinide analog
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23125
Abstract: Repaglinide (RPG) is an oral insulin secretagogue used in the treatment of diabetes. In this study, a new RPG analog was synthesized. Its antidiabetic and neuroprotective effects on dorsal root ganglions (DRG) in streptozotocin (STZ)‐induced… read more here.
Keywords: diabetic rats; antidiabetic neuroprotective; neuroprotective effects; effects novel ... See more keywords
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes
Sign Up to like & getrecommendations! Published in 2025 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-025-01141-w
Abstract: Diabetes mellitus induces adverse structural, electrophysiological and autonomic remodelling increasing the risk for life-threatening arrhythmias, particularly after acute myocardial infarction. Natriuretic peptides (NPs) show increasing evidence of antagonising arrhythmia. Our previous study demonstrated that C-type… read more here.
Keywords: cnp analogue; analogue vosoritide; type; stz induced ... See more keywords
Primary study on the hypoglycemic mechanism of 5rolGLP-HV in STZ-induced type 2 diabetes mellitus mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9809-7
Abstract: Abstract5rolGLP-HV is a promising dual-function peptide for the treatment of diabetes and thrombosis simultaneously. For investigating the therapeutic mechanism of 5rolGLP-HV for type 2 diabetes mellitus (T2DM), STZ-induced diabetic mice were established and treated with… read more here.
Keywords: stz induced; mechanism 5rolglp; type diabetes; diabetes mellitus ... See more keywords
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01170-5
Abstract: Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats.… read more here.
Keywords: stz induced; induced diabetic; tropisetron; foxo3a ... See more keywords
Potential therapeutic role of melatonin on STZ-induced diabetic central neuropathy: A biochemical, histopathological, immunohistochemical and ultrastructural study.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2018.09.008
Abstract: The aim of the present study was to assess the therapeutic potential of melatonin (Mel) in diabetic central neuropathy in a rat model of streptozotocin (STZ)-induced diabetes. The rats were injected with 60 mg/kg STZ and… read more here.
Keywords: stz induced; stz; induced diabetic; diabetic central ... See more keywords
Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition"
DOI: 10.1016/j.nut.2016.10.004
Abstract: OBJECTIVE The aim of this study was to observe whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5 F) cells against streptozotocin (STZ)-induced apoptosis in vitro and type 1 diabetes mellitus (T1DM) and type 2… read more here.
Keywords: t2dm; stz induced; vivo; rin5 cells ... See more keywords
Neuroprotective Effects of a Benzofuran-Containing Selenium in a Mouse Alzheimer’s Disease Model: Molecular, Biochemical, and Behavioral Analyses
Sign Up to like & getrecommendations! Published in 2025 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.5c00139
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder mainly characterized by progressive cognitive decline, for which effective treatments remain limited, and selenium is known for its neuroprotective actions. Thus, this study evaluated the neuroprotective effects of… read more here.
Keywords: alzheimer disease; selenium; stz induced; neuroprotective effects ... See more keywords
Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer’s disease-like pathology in hippocampal neuronal cells via the blocking of Ca2+/Calpain/Cdk5-mediated mitochondrial fragmentation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-66256-x
Abstract: Oxidative stress plays an essential role in the progression of Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder. Streptozotocin (STZ)-induced abnormal brain insulin signaling and oxidative stress play crucial roles in the progression of… read more here.
Keywords: like pathology; pathology; stz induced; ca2 ... See more keywords
Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the liver tissue of STZ-induced diabetes in mice
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-66426-x
Abstract: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It involves disturbances in carbohydrate, fat, and protein metabolism due to defects in insulin secretion, insulin action, or both. Novel therapeutic approaches are… read more here.
Keywords: kaempherol rhamnoside; enzyme activities; stz induced; ampk pathway ... See more keywords
In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Drug research"
DOI: 10.1055/a-0646-3803
Abstract: AIM The evaluation of the positive and protective effects thymol as a natural compound on the STZ -induced diabetic rats. MATERIALS AND METHODS In this study, seven groups of the streptozotocin induced diabetic and normal… read more here.
Keywords: status; liver kidney; stz induced; induced diabetic ... See more keywords
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1964894
Abstract: Excessive oxidative stress, inflammation, and myocardial hypertrophy have been associated with diabetic cardiomyopathy (DCM). S14G-humanin (HNG) is a potent humanin analogue that has demonstrated cytoprotective effects in a variety of cells and tissues. However, the… read more here.
Keywords: induced cardiac; stz induced; stz; s14g humanin ... See more keywords