Antidiabetic and neuroprotective effects of a novel repaglinide analog
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23125
Abstract: Repaglinide (RPG) is an oral insulin secretagogue used in the treatment of diabetes. In this study, a new RPG analog was synthesized. Its antidiabetic and neuroprotective effects on dorsal root ganglions (DRG) in streptozotocin (STZ)‐induced… read more here.
Keywords: diabetic rats; antidiabetic neuroprotective; neuroprotective effects; effects novel ... See more keywords
Primary study on the hypoglycemic mechanism of 5rolGLP-HV in STZ-induced type 2 diabetes mellitus mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9809-7
Abstract: Abstract5rolGLP-HV is a promising dual-function peptide for the treatment of diabetes and thrombosis simultaneously. For investigating the therapeutic mechanism of 5rolGLP-HV for type 2 diabetes mellitus (T2DM), STZ-induced diabetic mice were established and treated with… read more here.
Keywords: stz induced; mechanism 5rolglp; type diabetes; diabetes mellitus ... See more keywords
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01170-5
Abstract: Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats.… read more here.
Keywords: stz induced; induced diabetic; tropisetron; foxo3a ... See more keywords
Potential therapeutic role of melatonin on STZ-induced diabetic central neuropathy: A biochemical, histopathological, immunohistochemical and ultrastructural study.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2018.09.008
Abstract: The aim of the present study was to assess the therapeutic potential of melatonin (Mel) in diabetic central neuropathy in a rat model of streptozotocin (STZ)-induced diabetes. The rats were injected with 60 mg/kg STZ and… read more here.
Keywords: stz induced; stz; induced diabetic; diabetic central ... See more keywords
Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition"
DOI: 10.1016/j.nut.2016.10.004
Abstract: OBJECTIVE The aim of this study was to observe whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5 F) cells against streptozotocin (STZ)-induced apoptosis in vitro and type 1 diabetes mellitus (T1DM) and type 2… read more here.
Keywords: t2dm; stz induced; vivo; rin5 cells ... See more keywords
In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Drug research"
DOI: 10.1055/a-0646-3803
Abstract: AIM The evaluation of the positive and protective effects thymol as a natural compound on the STZ -induced diabetic rats. MATERIALS AND METHODS In this study, seven groups of the streptozotocin induced diabetic and normal… read more here.
Keywords: status; liver kidney; stz induced; induced diabetic ... See more keywords
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1964894
Abstract: Excessive oxidative stress, inflammation, and myocardial hypertrophy have been associated with diabetic cardiomyopathy (DCM). S14G-humanin (HNG) is a potent humanin analogue that has demonstrated cytoprotective effects in a variety of cells and tissues. However, the… read more here.
Keywords: induced cardiac; stz induced; stz; s14g humanin ... See more keywords
Liraglutide alleviates cardiac fibrosis through inhibiting P4h&agr;-1 expression in STZ-induced diabetic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmy177
Abstract: Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure. Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy. However, there is a lack of effective… read more here.
Keywords: fibrosis; stz induced; induced diabetic; group ... See more keywords
Alleviating effects of lupeol on postprandial hyperglycemia in diabetic mice.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology research"
DOI: 10.1093/toxres/tfab019
Abstract: This study aimed to investigate the inhibition activities of lupeol on carbohydrate digesting enzymes and its ability to improve postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. α-Glucosidase and α-amylase inhibitory assays were executed using a… read more here.
Keywords: stz induced; induced diabetic; hyperglycemia; mice ... See more keywords
Protective effects of sulforaphane on STZ‐induced diabetic retinopathy via activation of Nrf2/HO‐1 antioxidant pathway and inhibition of NADPH oxidase
Sign Up to like & getrecommendations! Published in 2017 at "Acta Ophthalmologica"
DOI: 10.1111/j.1755-3768.2017.01557
Abstract: Purpose To investigate the protective effects of sulforaphane, an Nrf2 activator, on streptozotocin (STZ)-induced diabetic retinopathy. Methods 8 wk male C57BL/6 mice were intraperitoneally injected with streptozotocin (STZ, 45 mg/kg) for 5 consective days. Animals with fasting… read more here.
Keywords: stz induced; stz; induced diabetic; effects sulforaphane ... See more keywords
Astragalus polysaccharides improve cardiomyopathy in STZ-induced diabetic mice and heterozygous (SOD2+/-) knockout mice
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20176204
Abstract: Oxidative stress plays an important role in the development of diabetic cardiomyopathy. In the present study, we determined whether the effect of astragalus polysaccharides (APS) on diabetic cardiomyopathy was associated with its impact on oxidative… read more here.
Keywords: stz induced; induced diabetic; stress; diabetic mice ... See more keywords