Exercise intervention attenuates neuropathic pain in diabetes via mechanisms of mammalian target of rapamycin (mTOR)
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2018.1489851
Abstract: Abstract This study was to examine the role of exercise intervention in modulating neuropathic pain induced by diabetes. Diabetes was induced by streptozotocin (STZ, i.p.) in rats and mechanical hyperalgesia was observed three weeks after… read more here.
Keywords: exercise intervention; mtor; stz rats; neuropathic pain ... See more keywords
Involvement of pro-inflammatory cytokines in diabetic neuropathic pain via central PI3K/Akt/mTOR signal pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2019.1651869
Abstract: The midbrain periaqueductal gray (PAG) is an important component of the descending inhibitory pathway controlling on central pain transmission. We examined the role of pro-inflammatory cytokines (PICs) of the PAG in regulating mechanical hyperalgesia and… read more here.
Keywords: pi3k akt; stz rats; neuropathic pain; akt mtor ... See more keywords
Stereological study on the number of synapses in the rat spinal dorsal horn with painful diabetic neuropathy induced by streptozotocin
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DOI: 10.1097/wnr.0000000000000762
Abstract: Our previous studies showed that direct injury to the sciatic nerve (chronic constriction injury or axotomy) is associated with a numerical increase in synaptic number in the rat spinal dorsal horn. The aim of this… read more here.
Keywords: spinal dorsal; dorsal horn; number; stz rats ... See more keywords
Blood-Brain Barrier Disruption Induced Cognitive Impairment Is Associated With Increase of Inflammatory Cytokine
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2018.00129
Abstract: Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic… read more here.
Keywords: cognitive impairment; impairment; stz rats; week stz ... See more keywords
Therapeutic Effect of Cilostazol Ophthalmic Nanodispersions on Retinal Dysfunction in Streptozotocin-Induced Diabetic Rats
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DOI: 10.3390/ijms18091971
Abstract: We previously prepared ophthalmic formulations containing cilostazol (CLZ) nanoparticles by bead mill methods (CLZnano), and found that instillation of CLZnano into rat eyes supplies CLZ into the retina. In this study, we investigated changes in… read more here.
Keywords: instillation clznano; streptozotocin induced; induced diabetic; streptozotocin ... See more keywords
Proteomic profile of the lens in a streptozotocin-induced diabetic rat model using shotgun proteomics.
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DOI: 10.3892/br.2017.988
Abstract: Streptozotocin (STZ)-induced diabetic rats (STZ rats) were used to investigate diabetic cataracts. In the current study, a shotgun liquid chromatography (LC)/mass spectrometry (MS)-based global proteomic analysis method was used to examine the mechanism of lens… read more here.
Keywords: compared normal; induced diabetic; normal rats; using shotgun ... See more keywords