Illuminating Sub‐Cellular Organelles by Small Molecule AIEgens
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200370
Abstract: Sub‐cellular organelles play a critical role in a myriad biological phenomena. Consequently, organelle structures and functions are invariably highjacked in diverse diseases including metabolic disorders, aging, and cancer. Hence, illuminating organelle dynamics is crucial in… read more here.
Keywords: small molecule; illuminating sub; cellular organelles; sub cellular ... See more keywords
Anthracene drives sub-cellular proteome-wide alterations in the degradative system of Penicillium oxalicum.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.04.051
Abstract: Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in polluted environments and are included in the priority list of toxic compounds. Previous studies have shown that the fungus Penicillium oxalicum, isolated from a hydrocarbon-polluted pond, has… read more here.
Keywords: anthracene drives; sub cellular; biodegradation; penicillium oxalicum ... See more keywords
Hazardous sub-cellular effects of Fipronil directly influence the organismal parameters of Spodoptera litura.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.01.076
Abstract: Indiscriminate use of insecticides/pesticides affects the structure and function of the ecosystems. The present study was aimed to investigate the toxic potential of Fipronil (a second generation phenylpyrazole) using Spodoptera litura larvae (Lepidoptera: Noctuidae) as… read more here.
Keywords: sub cellular; organismal parameters; influence organismal; spodoptera litura ... See more keywords
RNAi of arcRNA hsrω affects sub-cellular localization of Drosophila FUS to drive neurodiseases
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.03.011
Abstract: ABSTRACT Defective RNA metabolism is common pathogenic mechanisms involved in neurological disorders. Indeed, a conspicuous feature of some neurodegenerative diseases is the loss of nuclear activities of RNA‐binding proteins (RBPs) like Fused in sarcoma (FUS)… read more here.
Keywords: hsr ohgr; sub cellular; dfus; arcrna hsr ... See more keywords
Silicon Nanowires for Intracellular Optical Interrogation with Sub-Cellular Resolution.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b04624
Abstract: Current techniques for intracellular electrical interrogation are limited by substrate-bound devices, technically demanding methods, or insufficient spatial resolution. In this work, we use freestanding silicon nanowires to achieve photoelectric stimulation in myofibroblasts with subcellular resolution.… read more here.
Keywords: resolution; nanowires intracellular; silicon nanowires; sub cellular ... See more keywords
Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c00731
Abstract: Lactate is an energy substrate and an intercellular signal, which can be monitored in intact cells with the genetically encoded FRET indicator Laconic. However, the structural complexity, need for sophisticated equipment, and relatively small fluorescent… read more here.
Keywords: lactate; single fluorophore; sub cellular; fluorophore indicator ... See more keywords
Increased SERCA2a sub-cellular heterogeneity in right-ventricular heart failure inhibits excitation-contraction coupling and modulates arrhythmogenic dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0317
Abstract: The intracellular calcium handling system of cardiomyocytes is responsible for controlling excitation-contraction coupling (ECC) and has been linked to pro-arrhythmogenic cellular phenomena in conditions such as heart failure (HF). SERCA2a, responsible for intracellular uptake, is… read more here.
Keywords: excitation contraction; heterogeneity; heart failure; contraction coupling ... See more keywords
Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1101/2022.03.15.22272407
Abstract: Photoreceptor cells (PRCs) are the light-detecting cells of the retina. Such cells can be non-invasively imaged using optical coherence tomography (OCT) which is used in clinical settings to diagnose and monitor ocular diseases. Here we… read more here.
Keywords: disease; cellular level; variation; common genetic ... See more keywords
Sites of sub-cellular photodamage: Apoptotic and autophagic responses.
Sign Up to like & getrecommendations! Published in 2023 at "Photochemistry and photobiology"
DOI: 10.1111/php.13815
Abstract: Log dose-response curves relating to the effect of mitochondrial photodamage on clonogenic survival using benzoporphyrin derivative. With wild-type cells, autophagy produces a "shoulder" on the curve which is absent when an ATG5 knockdown is examined.… read more here.
Keywords: photodamage apoptotic; sites sub; sub cellular; apoptotic autophagic ... See more keywords
A semi-supervised Bayesian approach for simultaneous protein sub-cellular localisation assignment and novelty detection
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008288
Abstract: The cell is compartmentalised into complex micro-environments allowing an array of specialised biological processes to be carried out in synchrony. Determining a protein’s sub-cellular localisation to one or more of these compartments can therefore be… read more here.
Keywords: novelty detection; sub cellular; localisation; approach ... See more keywords
Advances in Computational Methodologies for Classification and Sub-Cellular Locality Prediction of Non-Coding RNAs
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168719
Abstract: Apart from protein-coding Ribonucleic acids (RNAs), there exists a variety of non-coding RNAs (ncRNAs) which regulate complex cellular and molecular processes. High-throughput sequencing technologies and bioinformatics approaches have largely promoted the exploration of ncRNAs which… read more here.
Keywords: sub cellular; coding rnas; cellular localization; non coding ... See more keywords