Abstract 3124: Identification of sub-clonal loss of heterozygosity (LOH) in glioblastomas analyzed with spatial transcriptomics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3124
Abstract: We propose a method to leverage spatial transcriptomics and bioinformatic analysis to identify sub-clonal loss of heterozygosity that could otherwise be missed by standard bulk sequencing in glioblastoma tumors. Glioblastomas are highly invasive and aggressive… read more here.
Keywords: loss heterozygosity; spatial transcriptomics; sub clonal; clonal loss ... See more keywords
First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer
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DOI: 10.1371/journal.pcbi.1010952
Abstract: The signature of early cancer dynamics on the spatial arrangement of tumour cells is poorly understood, and yet could encode information about how sub-clones grew within the expanding tumour. Novel methods of quantifying spatial tumour… read more here.
Keywords: cell; time; sub clonal; tumour ... See more keywords