Re-establishment of efficacy of tofacitinib, an oral JAK inhibitor, after temporary discontinuation in patients with rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-04956-1
Abstract: Introduction/objective Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). This post-hoc analysis evaluated the effect of temporary discontinuation and reinitiation of tofacitinib on disease control in patients with RA… read more here.
Keywords: treatment; efficacy; efficacy tofacitinib; sub study ... See more keywords
Smoking and overweight associated with masked uncontrolled hypertension: a Hypertension Optimal Treatment (HOT) Sub-Study
Sign Up to like & getrecommendations! Published in 2020 at "Blood Pressure"
DOI: 10.1080/08037051.2020.1787815
Abstract: Abstract Purpose The Hypertension Optimal Treatment (HOT) Study investigated the relationship between target office diastolic blood pressure (BP) ≤80, ≤85 or ≤90 mmHg and cardiovascular morbidity and mortality in 18,790 patients aged 50–80 years. The home BP… read more here.
Keywords: office; home; uncontrolled hypertension; hypertension ... See more keywords
Reduction of thrombus burden by cangrelor in ticagrelor-loaded st-elevation myocardial infarction patients with high residual platelet reactivity: the imaging sub-study of the ERMIT randomized trial
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.2377
Abstract: Residual high platelet reactivity (HPR) at the time of primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is associated with higher residual thrombus burden and the subsequent suboptimal reperfusion. We sought to determine… read more here.
Keywords: cangrelor; sub study; thrombus burden;
P4772Role of anticoagulation in patients with subclinical AF and its association with cardiovascular events: a SILENT sub study
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.1148
Abstract: Atrial fibrillation (AF) is a well-established thromboembolic event risk factor. Episodes of subclinical AF (SCAF) recorded in implantable electronic cardiac devices (IECD) have been related to clinical AF and increased risk of stroke. However, there… read more here.
Keywords: anticoagulation; group; study; rate ... See more keywords
Effect of renal artery revascularization upon cardiac structure and function in atherosclerotic renal artery stenosis: cardiac magnetic resonance sub-study of the ASTRAL trial
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfw107
Abstract: Background Cardiac abnormalities are frequent in patients with atherosclerotic renovascular disease (ARVD). The Angioplasty and Stenting for Renal Artery Lesions (ASTRAL) trial studied the effect of percutaneous renal revascularization combined with medical therapy compared with… read more here.
Keywords: renal artery; artery; astral trial; versus ... See more keywords
Electrolyte profiles with induced hypothermia: a sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest.
Sign Up to like & getrecommendations! Published in 2022 at "Acta anaesthesiologica Scandinavica"
DOI: 10.1111/aas.14053
Abstract: BACKGROUND Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM. METHODS This is a… read more here.
Keywords: hypothermia; cardiac arrest; concentration; electrolyte ... See more keywords
Abstract P5-21-23: Evaluation of the drug interaction potential of palbociclib and exemestane – Results from the PEARL pharmacokinetic sub-Study
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-p5-21-23
Abstract: Background: Palbociclib (PAL) is an oral cyclin-dependent kinase (CDK) 4/6 inhibitor that is under investigation in multiple oncologic clinical trials and is currently approved for use in combination with aromatase inhibitors (AIs) or fulvestrant (FUL)… read more here.
Keywords: drug; pal exe; study; sub study ... See more keywords
A Phase 1 Study Investigating the Safety and Efficacy of Danvatirsen As Monotherapy Followed By Combination with Venetoclax in Patients with Relapsed/Refractory MDS and AML
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DOI: 10.1182/blood-2024-208998
Abstract: Background: In spite of the emergence of targeted & novel therapies, only 30% of patients with newly diagnosed acute myeloid leukemia (AML) enjoy long-term survival, while the majority still succumb to their illness. Even patients… read more here.
Keywords: study; danvatirsen monotherapy; mds; sub study ... See more keywords
Demographics, Characteristics, Survival and Outcomes in Older, Untreated, Acute Myeloid Leukemia Patients with NPM1 Mutations or KMT2A rearrangements from the Beat AML Master Clinical Trial
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DOI: 10.1182/blood-2024-211261
Abstract: Background: Chromosomal rearrangements involving the KMT2A gene and mutations involving the nucleophosmin (NPM1) gene have been associated with response to menin inhibitors in multiple studies of acute myeloid leukemia (AML) patients characterized by these genetic… read more here.
Keywords: treatment; cohort; aml patients; ven hma ... See more keywords
The challenge of planning learning opportunities for clinical medicine: a triangulation study in Iran
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Education"
DOI: 10.1186/s12909-019-1719-3
Abstract: BackgroundAn essential characteristics of clinical education is the need to learn a large number of practical and communication skills along with theoretical knowledge. It is challenging to design learning opportunities (LOs) for clinical setting. We… read more here.
Keywords: medical schools; learning opportunities; medicine; study ... See more keywords
A mixed-methods study on the course of professional identity formation in undergraduate medical students
Sign Up to like & getrecommendations! Published in 2025 at "BMC Medical Education"
DOI: 10.1186/s12909-025-07162-2
Abstract: This study explored the development of professional identity formation (PIF) in medical students during clinical rotations, focusing on the relationship between self-perceived development and actual development. It examined feedback and evaluations within the entrustable professional… read more here.
Keywords: identity formation; identity; medical students; sub study ... See more keywords