Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.32900
Abstract: Cdc6 is a key replication licencing factor with a pivotal role in regulating the process of DNA replication, rendering it an important investigatory focus in tumourigenesis. Indeed, Cdc6 overexpression has been found to be a… read more here.
Keywords: subcellular localisation; senescence; pancreatic cancer; cdc6 ... See more keywords
The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27233-3
Abstract: Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1Ea, proIGF-1Eb and proIGF-1Ec. These proIGF-1s have a… read more here.
Keywords: mature; production; proigf 1ea; subcellular localisation ... See more keywords
Identifying protein subcellular localisation in scientific literature using bidirectional deep recurrent neural network
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80441-8
Abstract: The increased diversity and scale of published biological data has to led to a growing appreciation for the applications of machine learning and statistical methodologies to gain new insights. Key to achieving this aim is… read more here.
Keywords: subcellular localisation; neural network; protein subcellular;