Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepters
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202211597
Abstract: The spatiotemporal characterization of signaling crosstalk between subcellular organelles is crucial for the therapeutic effect of malignant tumors. Blocking interactive crosstalk in this fashion is significant but challenging. Herein, a communication interception strategy is reported,… read more here.
Keywords: subcellular organelles; spatiotemporal crosstalk; anticancer; therapy ... See more keywords
Enzymatic Noncovalent Synthesis for Targeting Subcellular Organelles.
Sign Up to like & getrecommendations! Published in 2022 at "ChemPlusChem"
DOI: 10.1002/cplu.202200060
Abstract: Enzymatic noncovalent synthesis (ENS) exploits enzymatic reactions to produce spatially organized higher-order supramolecular assemblies that modulate cellular processes. While ENS is a general mechanism to create higher-order assemblies of proteins for diverse cellular functions, the… read more here.
Keywords: synthesis targeting; subcellular organelles; noncovalent synthesis; targeting subcellular ... See more keywords
Protein-retention expansion microscopy for visualizing subcellular organelles in fixed brain tissue
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2021.109285
Abstract: BACKGROUND Protein expansion microscopy (proExM) is a powerful technique that crosslinks proteins to a swellable hydrogel to physically expand and optically clear biological samples. The resulting increased resolution (~70nm) and physical separation of labeled proteins… read more here.
Keywords: microscopy; visualizing subcellular; brain; expansion microscopy ... See more keywords
Fluorescent probes for imaging bioactive species in subcellular organelles.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04273d
Abstract: Luminescent molecular probes and nanoscale materials have become important tools in biosensing and bioimaging applications because of their high sensitivity, fast response, specificity, and methodological simplicity. In recent years, there has been a notable advancement… read more here.
Keywords: species subcellular; bioactive species; imaging bioactive; probes imaging ... See more keywords
Characterization of Subcellular Organelles in Cortical Perisynaptic Astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.573944
Abstract: Perisynaptic astrocytic processes (PAPs) carry out several different functions, from metabolite clearing to control of neuronal excitability and synaptic plasticity. All these functions are likely orchestrated by complex cellular machinery that resides within the PAPs… read more here.
Keywords: perisynaptic astrocytes; microscopy; cortical perisynaptic; characterization subcellular ... See more keywords
Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21249696
Abstract: Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted… read more here.
Keywords: nanoparticles targeting; mesoporous silica; silica nanoparticles; targeting subcellular ... See more keywords