Subcellular-Scale Drug Transport via Ultrasound-Degradable Mesoporous Nanosilicon to Bypass Cancer Drug Resistance.
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DOI: 10.1002/smll.201604228
Abstract: Delivering and releasing anticancer agents directly to their subcellular targets of action in a controlled manner are almost the ultimate goal of pharmacology, but it is challenging. In recent decades, plenty of efforts have been… read more here.
Keywords: drug resistance; subcellular scale; drug; cancer ... See more keywords
Measurement of Absolute Concentration at the Subcellular Scale.
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DOI: 10.1021/acsnano.0c04285
Abstract: The concentration of a pharmaceutical drug or bioactive metabolite within the target organelle influences the effects elicited by the drug or metabolite. Although the relative concentrations of many compounds of interest within subcellular compartments have… read more here.
Keywords: absolute concentration; subcellular scale; concentration subcellular; measurement absolute ... See more keywords
Topography on a subcellular scale modulates cellular adhesions and actin stress fiber dynamics in tumor associated fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Physical biology"
DOI: 10.1088/1478-3975/aa7acc
Abstract: Cells can sense and adapt to mechanical properties of their environment. The local geometry of the extracellular matrix, such as its topography, has been shown to modulate cell morphology, migration, and proliferation. Here we investigate… read more here.
Keywords: topography; stress fiber; tumor associated; subcellular scale ... See more keywords