A Bio‐Conjugated Fullerene as a Subcellular‐Targeted and Multifaceted Phototheranostic Agent
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202101527
Abstract: Fullerenes are candidates for theranostic applications because of their high photodynamic activity and intrinsic multimodal imaging contrast. However, fullerenes suffer from low solubility in aqueous media, poor biocompatibility, cell toxicity, and a tendency to aggregate.… read more here.
Keywords: bio conjugated; c70; subcellular targeted; conjugated fullerene ... See more keywords
Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01653
Abstract: In this study, we linked classical organelle-targeting groups, such as triphenylphosphonium, pentafluorobenzene, and morpholine, to our previously reported potent monoiodo Aza-BODIPY photosensitizer (BDP-15). They were conveniently prepared and retained the advantages of Aza-BODIPY PS with… read more here.
Keywords: discovery subcellular; subcellular targeted; antitumor; targeting groups ... See more keywords
Lysosome passivation triggered by silver nanoparticles enhances subcellular-targeted drug therapy.
Sign Up to like & getrecommendations! Published in 2024 at "Nanoscale"
DOI: 10.1039/d4nr00451e
Abstract: Frequently, subcellular-targeted drugs tend to accumulate in lysosomes after cellular absorption, a process termed the lysosomal trap. This accumulation often interferes with the drug's ability to bind to its target, resulting in decreased efficiency. Existing… read more here.
Keywords: subcellular targeted; lysosome passivation; cy3 nps; drug ... See more keywords