Abstract B102: Using subclonal dynamics to detect and quantify fitness advantages of resistant subclones in tumors under treatment
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-b102
Abstract: In a tumor undergoing evolution under treatment, two forces drive changes in the frequencies of genetically distinct subpopulations (subclones): drift and natural selection. To identify the presence of a subclone with a fitness advantage in… read more here.
Keywords: fitness; treatment; subclonal dynamics; size ... See more keywords
Abstract 122: The subclonal dynamics of gross ploidy alterations in TNBC cells under chemotherapeutic pressure
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-122
Abstract: Solid tumors such as triple-negative breast cancer (TNBC) have characteristically high rates of aneuploidy and polyploidy. Chromosome-level aneuploidies are known to arise through errors in cytokinesis, but many of the mechanisms which drive large-scale ploidy… read more here.
Keywords: cell; subclonal dynamics; dynamics gross; ploidy ... See more keywords