Single‐Cell RNA‐seq Reveals a Developmental Hierarchy Super‐Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer
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DOI: 10.1002/advs.202105530
Abstract: Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation state and the interplay between… read more here.
Keywords: cell; subclonal evolution; prostate cancer; ecosystem ... See more keywords
Combating subclonal evolution of resistant cancer phenotypes
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DOI: 10.1038/s41467-017-01174-3
Abstract: Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. This acquired drug resistance is largely due to drug-refractory sub-populations (subclones) within heterogeneous tumors. Here, we track the genetic and phenotypic… read more here.
Keywords: evolution; breast; treatment; subclonal evolution ... See more keywords
Modeling the Subclonal Evolution of Cancer Cell Populations.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1229
Abstract: Increasing evidence shows that tumor clonal architectures are often the consequence of a complex branching process, yet little is known about the expected dynamics and extent to which these divergent subclonal expansions occur. Here, we… read more here.
Keywords: dominant clones; subclonal evolution; cancer cell; cancer ... See more keywords
Abstract 4295: Streamlining the reconstruction of subclonal evolution in DNA sequencing data
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4295
Abstract: In many cancer types, the evolution of subclonal malignant cells leads to a diverse tumor population that can affect treatment efficacy. In addition, evolution throughout treatment can lead to resistant subclonal populations and eventual relapse.… read more here.
Keywords: subclonal evolution; reconstruction subclonal; streamlining reconstruction; tumor ... See more keywords