Evolutionary dynamics and significance of multiple subclonal mutations in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "DNA repair"
DOI: 10.1016/j.dnarep.2017.06.002
Abstract: For the last 40 years the authors have collaborated on trying to understand the complexities of human cancer by formulating testable mathematical models that are based on mutation accumulation in human malignancies. We summarize the… read more here.
Keywords: subclonal mutations; multiple subclonal; dynamics significance; cancer ... See more keywords
Dissecting and analyzing the Subclonal Mutations Associated with Poor Prognosis in Diffuse Glioma
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4919111
Abstract: The prognostic and therapeutic implications in diffuse gliomas are still challenging. In this study, we first performed an integrative framework to infer the clonal status of mutations in glioblastomas (GBMs) and low-grade gliomas (LGGs) by… read more here.
Keywords: prognosis; clonal status; mutations associated; poor prognosis ... See more keywords