A statistical learning method for simultaneous copy number estimation and subclone clustering with single-cell sequencing data
Sign Up to like & getrecommendations! Published in 2024 at "Genome Research"
DOI: 10.1101/gr.278098.123
Abstract: The availability of single-cell sequencing (SCS) enables us to assess intra-tumor heterogeneity and identify cellular subclones without the confounding effect of mixed cells. Copy number aberrations (CNAs) have been commonly used to identify subclones in… read more here.
Keywords: cell sequencing; single cell; subclone; cell ... See more keywords
Abstract B102: Using subclonal dynamics to detect and quantify fitness advantages of resistant subclones in tumors under treatment
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-b102
Abstract: In a tumor undergoing evolution under treatment, two forces drive changes in the frequencies of genetically distinct subpopulations (subclones): drift and natural selection. To identify the presence of a subclone with a fitness advantage in… read more here.
Keywords: fitness; treatment; subclonal dynamics; size ... See more keywords
Abstract 4689: Subclone-specific evolution of tumor phenotypes – A framework to study subclone-specific gene expression from a combination of bulk DNA and single cell RNA sequencing data
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-4689
Abstract: Several approaches are now available for subclonal reconstruction of heterogeneous tumor biopsies from somatic variant allele frequencies measured in bulk DNA sequencing datasets, including our own SubcloneSeeker program. However, to understand how chemoresistance, relapse, or… read more here.
Keywords: bulk dna; tumor; cell; subclone specific ... See more keywords
Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008274
Abstract: Multidrug-resistant Escherichia coli ST131 fimH30 responsible for extra-intestinal pathogenic (ExPEC) infections is globally distributed. However, the occurrence of a subclone fimH27 of ST131 harboring both ExPEC and enteroaggregative E. coli (EAEC) related genes and belonging… read more here.
Keywords: mozambican children; subclone; escherichia coli; st131 ... See more keywords
Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00221
Abstract: Immunoglobulin repertoire sequencing has successfully been applied to identify expanded antigen-activated B-cell clones that play a role in the pathogenesis of immune disorders. One challenge is the selection of the Ag-specific B cells from the… read more here.
Keywords: subclone; abundancy affinity; affinity; repertoire sequencing ... See more keywords
Life and death of molecular subclones in recurrent meningioma: A case study.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical neuropathology"
DOI: 10.5414/np301365
Abstract: Meningiomas are the most common primary intracranial tumors, of which atypical meningiomas account for ~ 20%. A loss of NF2 has been proven to be an initial step for meningioma development; however, the role of non-NF2… read more here.
Keywords: case; subclone; mutation; non nf2 ... See more keywords