126 Subcortical maternal complex (SCMC) expression during folliculogenesis is affected by oocyte donor age in sheep
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv32n2ab126
Abstract: Age-associated decline in female fertility is largely attributable to decrease in oocyte quality. However, the molecular mechanisms that shape oocyte developmental competence, and that may be involved in reproductive aging, are yet to be elucidated.… read more here.
Keywords: age; scmc; oocyte; folliculogenesis ... See more keywords
Germline variants in genes of the subcortical maternal complex and Multilocus Imprinting Disturbance are associated with miscarriage/infertility or Beckwith–Wiedemann progeny
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Epigenetics"
DOI: 10.1186/s13148-022-01262-2
Abstract: Beckwith–Wiedemann syndrome (BWS, OMIM # 130650) is an imprinting disorder, associated with overgrowth and increased risk of embryonal tumors. Patients carrying hypomethylation in the KCNQ1OT1 :TSS DMR (11p15.5) show MLID (Multilocus Imprinting Disturbance) upon epimutations… read more here.
Keywords: subcortical maternal; imprinting disturbance; maternal complex; beckwith wiedemann ... See more keywords
Variants of NLRP genes encoding subcortical maternal complex components are linked to biparental placental mesenchymal dysplasia
Sign Up to like & getrecommendations! Published in 2025 at "Human Genomics"
DOI: 10.1186/s40246-025-00814-w
Abstract: Placental mesenchymal dysplasia (PMD) is a placental abnormality resembling partial hydatidiform moles without trophoblastic proliferation. Although many PMD cases involve androgenetic/biparental mosaicism or chimerism, we recently reported that approximately 30% of cases retain biparental genomes… read more here.
Keywords: maternal complex; subcortical maternal; methylation; aberrant methylation ... See more keywords