Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.06.029
Abstract: Protein aggregates are one of the several risk factors for undesired immunogenicity of biopharmaceuticals. However, it remains unclear which features determine whether aggregates will trigger an unwanted immune response. The aim of this study was… read more here.
Keywords: size particles; submicron size; soluble oligomers; micron size ... See more keywords
C-Terminal Lysine Processing of IgG in Human Suction Blister Fluid: Implications for Subcutaneous Administration.
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DOI: 10.1021/acs.molpharmaceut.2c00506
Abstract: C-terminal lysine (CTK) is often classified as a potential critical quality attribute for therapeutic antibodies being developed for subcutaneous (SC) administration because of its potential to impact antibody SC bioavailability/pharmacokinetics (PK). This classification both inflates… read more here.
Keywords: suction blister; terminal lysine; administration; subcutaneous administration ... See more keywords
Subcutaneous Administration of Medications and Fluids by Nonprofessional Caregivers at Home.
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DOI: 10.1089/jpm.2022.0107
Abstract: Background: Patients requiring home-based palliative care have advanced complex illnesses with functional limitations and decline. This retrospective study reviewed caregiver administration of subcutaneous (SQ) medications and fluids when symptom control could not be achieved using… read more here.
Keywords: administration; nonprofessional caregivers; subcutaneous administration; medications fluids ... See more keywords
Spider‐like injection site reaction after subcutaneous administration of haematological treatments
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DOI: 10.1111/jdv.16049
Abstract: While injection-site reactions to subcutaneous (SC) administration of anti-cancer agents are a regular phenomenon, up until now they have been unclearly described. They usually follow a benign course with spontaneous regression in a few days.… read more here.
Keywords: subcutaneous administration; injection site; spider like; injection ... See more keywords
Recurrent injection‐site reactions after incorrect subcutaneous administration of a COVID‐19 vaccine
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DOI: 10.1111/jdv.17341
Abstract: Local reactions to SARS-CoV-2 vaccination are common and mainly occur within the first week, albeit also seen later.1 Here, we address another aspect of cutaneous side effects to SARS-CoV-2 vaccination and draw attention to implications… read more here.
Keywords: injection site; incorrect subcutaneous; site reactions; subcutaneous administration ... See more keywords
Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration
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DOI: 10.3389/fvets.2022.968973
Abstract: Background Stressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats. Objectives The objectives for… read more here.
Keywords: administration; esomeprazole goats; intravenous subcutaneous; half life ... See more keywords