Evaluation of the Effects of a Monthly Buprenorphine Depot Subcutaneous Injection on QT Interval During Treatment for Opioid Use Disorder
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1406
Abstract: Extensive 12‐lead electrocardiogram monitoring and drug concentrations were obtained during development of BUP‐XR, a monthly subcutaneous injection for the treatment of opioid use disorder (OUD). Matched QT and plasma drug concentrations (11,925) from 1,114 subjects… read more here.
Keywords: use disorder; opioid use; subcutaneous injection; treatment opioid ... See more keywords
An observational time and motion study of denosumab subcutaneous injection and zoledronic acid intravenous infusion in patients with metastatic bone disease: results from three European countries
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DOI: 10.1007/s00520-017-3697-5
Abstract: PurposeDenosumab (administered via subcutaneous injection) demonstrated superior efficacy versus the intravenously administered zoledronic acid in the prevention of skeletal-related events in an integrated analysis of three head-to-head phase III trials in patients with bone metastases… read more here.
Keywords: time motion; time; observational time; zoledronic acid ... See more keywords
Simple Approach to Accurately Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies after Subcutaneous Injection in Humans
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DOI: 10.1007/s40262-020-00917-8
Abstract: Background and objective The subcutaneous injection of therapeutic monoclonal antibodies is increasingly used in the treatment of several diseases because of its convenience. Thus, a simple and accurate method of predicting the pharmacokinetics of monoclonal… read more here.
Keywords: injection humans; monoclonal antibodies; antibodies subcutaneous; approach ... See more keywords
Cutaneous infection by Mycobacterium lentiflavum after subcutaneous injection of lipolytic formula☆☆☆
Sign Up to like & getrecommendations! Published in 2020 at "Anais Brasileiros de Dermatologia"
DOI: 10.1016/j.abd.2019.11.013
Abstract: The incidence of nontuberculous mycobacterial infections is increasing worldwide; by 2017, more than 190 species and subspecies have been documented. Although classically associated with immunosuppression, the recognition of these etiological agents in diseases affecting immunocompetent… read more here.
Keywords: injection lipolytic; mycobacterium lentiflavum; subcutaneous injection; cutaneous infection ... See more keywords
Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.06.003
Abstract: With the rising cost of drug research, "do more with less" has become a new emphasis in the pharmaceutical industry. Consequently, the early analysis of pharmacokinetic/pharmacodynamic, efficacy, and safety parameters for a new drug target… read more here.
Keywords: absorption; delivery; drug; suspension ... See more keywords
A Review of Formulations of Commercially Available Antibodies.
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DOI: 10.1016/j.xphs.2021.03.017
Abstract: This review identified 126 commercially available antibodies approved globally between 1986 and February 2021 including 10 antibody drug conjugates, 16 biosimilars, and 3 antibody fragments. Prior to 2014 there were ≤ 5 approved each year,… read more here.
Keywords: volume; available antibodies; commercially available; contain ... See more keywords
SUBCUTANEOUS INJECTIONS: A CROSS-SECTIONAL STUDY OF KNOWLEDGE AND PRACTICE PREFERENCES OF NURSES.
Sign Up to like & getrecommendations! Published in 2023 at "Contemporary nurse"
DOI: 10.1080/10376178.2023.2209207
Abstract: BACKGROUND Widespread use of subcutaneous injection for parenteral medications is likely to be related to high medication bioavailability and rapid onset of action. Correct subcutaneous injection technique and site selection are essential for nursing care… read more here.
Keywords: injection; subcutaneous injection; practice; site ... See more keywords
MPET2: a multi-network poroelastic and transport theory for predicting absorption of monoclonal antibodies delivered by subcutaneous injection
Sign Up to like & getrecommendations! Published in 2023 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2163003
Abstract: Abstract Subcutaneous injection of monoclonal antibodies (mAbs) has attracted much attention in the pharmaceutical industry. During the injection, the drug is delivered into the tissue producing strong fluid flow and tissue deformation. While data indicate… read more here.
Keywords: injection; subcutaneous injection; multi network; model ... See more keywords
Ofatumumab subcutaneous injection for the treatment of relapsing forms of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2031982
Abstract: ABSTRACT Introduction In recent years, different studies have highlighted the importance of B cells in the pathophysiology of multiple sclerosis (MS): they secrete cytokines to modulate the inflammatory environment, present antigens for the activation of… read more here.
Keywords: subcutaneous injection; injection treatment; ofatumumab subcutaneous; treatment ... See more keywords
Subcutaneous injection of methotrexate: advantages in the treatment of rheumatoid arthritis.
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DOI: 10.1093/mr/roac156
Abstract: Methotrexate is a conventional synthetic disease-modifying anti-rheumatic drug, that is used in the treatment of rheumatoid arthritis. However, insufficient responses to oral methotrexate at lower doses as well as increased variation of drug bioavailability and… read more here.
Keywords: treatment rheumatoid; subcutaneous injection; rheumatoid arthritis; methotrexate ... See more keywords
Under the Skin: The Relationship Between Subcutaneous Injection and Skin Infections Among People Who Inject Drugs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Addiction Medicine"
DOI: 10.1097/adm.0000000000000844
Abstract: Objectives: People who inject drugs (PWID) are at increased risk for numerous negative health outcomes. Subcutaneous injections (aka skin popping) can result in greater risk of skin and soft tissue infections (SSTIs), but less is… read more here.
Keywords: people inject; injection; risk; subcutaneous injection ... See more keywords