The subfornical organ regulates acidosis‐evoked fear by engaging microglial acid‐sensor TDAG8 and forebrain neurocircuits in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25059
Abstract: An important role of pH homeostasis has been suggested in the physiology of panic disorder, with acidosis as an interoceptive trigger leading to fear and panic. Identification of novel mechanisms that can translate acidosis into… read more here.
Keywords: acidosis; acid; physiology; fear ... See more keywords
The subfornical organ in sodium appetite: Recent insights
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.08.012
Abstract: To maintain sodium homeostasis, animals will readily seek and ingest salt when salt-depleted, even at concentrations that they typically find aversive when sodium replete. This innate behaviour is known as sodium (or salt) appetite. Salt… read more here.
Keywords: subfornical organ; organ sodium; sodium; salt appetite ... See more keywords
Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease
Sign Up to like & getrecommendations! Published in 2023 at "Renal Failure"
DOI: 10.1080/0886022x.2023.2171886
Abstract: Abstract Objectives Subfornical organ (SFO) is vital in chronic kidney disease (CKD) progression caused by high salt levels. The current study investigated the effects of high salt on phosphoproteomic changes in SFO in CKD rats.… read more here.
Keywords: chronic kidney; high salt; group; kidney disease ... See more keywords
The subfornical organ drives hypertension in polycystic kidney disease via the hypothalamic paraventricular nucleus.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab122
Abstract: AIMS Hypertension is a prevalent yet poorly understood feature of polycystic kidney disease. Previously we demonstrated that increased glutamatergic neurotransmission within the hypothalamic paraventricular nucleus produces hypertension in the Lewis Polycystic Kidney rat model of… read more here.
Keywords: kidney; subfornical organ; paraventricular nucleus; polycystic kidney ... See more keywords
Identification of Clinical Factors Related to Antibody-Mediated Immune Response to the Subfornical Organ.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical endocrinology"
DOI: 10.1111/cen.14737
Abstract: OBJECTIVE We recently reported cases of adipsic hypernatremia caused by autoantibodies against the subfornical organ in patients with hypothalamic-pituitary lesions. This study aimed to clarify the clinical features of newly identified patients with adipsic hypernatremia… read more here.
Keywords: response; adipsic hypernatremia; antibody; subfornical organ ... See more keywords
Brain‐derived neurotrophic factor acts at neurons of the subfornical organ to influence cardiovascular function
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13704
Abstract: Brain‐derived neurotrophic factor (BDNF), a neurotrophin traditionally associated with neural plasticity, has more recently been implicated in fluid balance and cardiovascular regulation. It is abundantly expressed in both the central nervous system (CNS) and peripheral… read more here.
Keywords: brain derived; derived neurotrophic; subfornical organ; neurotrophic factor ... See more keywords