Differential Treatment Effects of Subgroup Analyses in Phase 3 Oncology Trials From 2004 to 2020
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.3379
Abstract: Key Points Question Among phase 3 oncology trials, how often do subgroup analyses support claims of differential treatment effects? Findings In this cross-sectional study of 379 published phase 3 randomized clinical trials with subgroup analyses,… read more here.
Keywords: oncology; subgroup analyses; differential treatment; phase ... See more keywords
Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13122
Abstract: This study aimed to investigate the reporting of subgroup analyses in heart failure (HF) randomized controlled trials (RCTs) and to determine the strength and credibility of subgroup claims. read more here.
Keywords: subgroup; subgroup analyses; analyses heart; heart failure ... See more keywords
Identifying Which Urban Children With Asthma Benefit Most From Clinician Prompting: Subgroup Analyses From the Prompting Asthma Intervention in Rochester-Uniting Parents and Providers (PAIR-UP) Trial.
Sign Up to like & getrecommendations! Published in 2018 at "Academic pediatrics"
DOI: 10.1016/j.acap.2017.08.015
Abstract: OBJECTIVE Clinician prompts increase the likelihood of guideline-recommended corrective actions (preventive medication prescription, dose change, and/or adherence promotion) for symptomatic children with poorly controlled or persistent asthma in the primary care setting, but it is… read more here.
Keywords: intervention; corrective actions; subgroup analyses; medication use ... See more keywords
Prespecification of subgroup analyses and examination of treatment-subgroup interactions in cancer individual participant data meta-analyses are suboptimal.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2021.06.019
Abstract: OBJECTIVES This study aimed to explore the prespecification and conduct of subgroup analyses in cancer individual participant data meta-analyses (IPDMAs). STUDY DESIGN AND SETTING We searched PubMed, Embase, Cochrane Library, and Web of Science to… read more here.
Keywords: subgroup; treatment subgroup; subgroup analyses; cancer ... See more keywords
A survey of stakeholders' perceived importance of health indicators and subgroup analyses to inform the Canadian clinical practice guideline for managing paediatric obesity
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Obesity"
DOI: 10.1111/ijpo.12949
Abstract: To assess stakeholder ratings of health indicators and subgroup analyses in systematic reviews used to update the Canadian Clinical Practice Guideline for Managing Paediatric Obesity. read more here.
Keywords: health indicators; subgroup analyses; clinical practice; indicators subgroup ... See more keywords
Safety and efficacy of Pazopanib in advanced soft tissue sarcoma: PALETTE (EORTC 62072) subgroup analyses
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5988-3
Abstract: BackgroundPALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between patient characteristics, prior lines of therapy, dose… read more here.
Keywords: pazopanib; advanced soft; efficacy; subgroup analyses ... See more keywords
Subgroup analyses from READY: Real-world data from an Italian compassionate use program (CUP) of avelumab first-line maintenance (1LM) treatment for locally advanced or metastatic urothelial carcinoma (la/mUC).
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.4_suppl.558
Abstract: 558 Background: A multicenter CUP provided early access to avelumab 1LM in Italian patients (pts) with Ia/mUC before reimbursement. Real-world pt characteristics and outcomes with avelumab 1LM from READY were reported previously. Here, we report… read more here.
Keywords: subgroup analyses; avelumab 1lm; real world; pbc ... See more keywords