Subgroup-specific dose finding for phase I-II trials using Bayesian clustering.
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in medicine"
DOI: 10.1002/sim.9410
Abstract: In most models and algorithms for dose-finding clinical trials, it is assumed that the trial participants are homogeneous-the optimal dose is the same for all those who qualify for the trial. However, if there are… read more here.
Keywords: bayesian clustering; dose finding; methodology; subgroup specific ... See more keywords
Research Note: Detection of Avian metapneumovirus subgroup C specific antibodies in a mallard flock in Italy
Sign Up to like & getrecommendations! Published in 2021 at "Poultry Science"
DOI: 10.1016/j.psj.2021.101186
Abstract: Avian metapneumovirus (aMPV) is a viral pathogen that causes respiratory signs and drops in egg production most notably in turkeys but also affects chickens, ducks and other species. Four subgroups (aMPV-A, -B, -C and -D)… read more here.
Keywords: avian metapneumovirus; specific antibodies; flock; subgroup specific ... See more keywords
Inferring subgroup-specific driver genes from heterogeneous cancer samples via subspace learning with subgroup indication
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz793
Abstract: MOTIVATION Detecting driver genes from gene mutation data is a fundamental task for tumorigenesis research. Due to the fact that cancer is a heterogeneous disease with various subgroups, subgroup specific driver genes are the key… read more here.
Keywords: driver; driver genes; subgroup specific; specific driver ... See more keywords
Neoplastic and immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab135
Abstract: BACKGROUND Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease progression. We aimed to determine the influence of neoplastic and immune cell diversity on MB biology in… read more here.
Keywords: single cell; cell; subgroup specific; neoplastic immune ... See more keywords
MDB-59. INTEGRATIVE PROTEO-GENOMICS TO DECIPHER MOLECULAR MECHANISMS UNDERLYING SUBGROUP-SPECIFIC HETEROGENEITY IN MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.508
Abstract: Abstract BACKGROUND Medulloblastoma (MB), an aggressive pediatric brain cancer, poses significant treatment challenges due to its complex disease biology, comprising a collection of discrete molecular subtypes that require different treatment. Although the genomics, transcriptomics, and… read more here.
Keywords: underlying subgroup; subgroup specific; mechanisms underlying; biology ... See more keywords
TMET-21. METABOLIC PROFILING OF MENINGIOMA REVEALS NOVEL SUBGROUP-SPECIFIC BIOLOGIC INSIGHTS AND OUTCOME DEPENDENCIES
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.1159
Abstract: Prior studies have elucidated the presence of four consensus molecular groups (MGs) of meningioma, with unique underlying biology and outcomes. The hyperactivation of metabolic pathways may be associated with tumour growth in so-called hypermetabolic (MG3)… read more here.
Keywords: metabolic profiling; subgroup specific; outcome; worse outcomes ... See more keywords
Abstract IA03: Subgroup-specific enhancer hijacking in medulloblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca17-ia03
Abstract: In recent years, next-generation sequencing has uncovered the spectrum of driver genes and molecular processes contributing to most cancer entities, including pediatric cancer. This holds true for medulloblastoma (MB), the most common malignant childhood brain… read more here.
Keywords: subgroup specific; medulloblastoma; enhancer hijacking; cancer ... See more keywords
The Effects of Subgroup-Specific Accountability on Teacher Turnover and Attrition
Sign Up to like & getrecommendations! Published in 2018 at "Education Finance and Policy"
DOI: 10.1162/edfp_a_00227
Abstract: The No Child Left Behind Act of 2001 required states to set cutoffs to determine which schools were subject to accountability for their racial/ethnic subgroups. Using a regression discontinuity design and data from North Carolina,… read more here.
Keywords: subgroup specific; teacher turnover; specific accountability; turnover attrition ... See more keywords
Comparing Bayesian hierarchical meta-regression methods and evaluating the influence of priors for evaluations of surrogate endpoints on heterogeneous collections of clinical trials
Sign Up to like & getrecommendations! Published in 2024 at "BMC Medical Research Methodology"
DOI: 10.1186/s12874-024-02170-0
Abstract: Background Surrogate endpoints, such as those of interest in chronic kidney disease (CKD), are often evaluated using Bayesian meta-regression. Trials used for the analysis can evaluate a variety of interventions for different sub-classifications of disease,… read more here.
Keywords: meta; subgroup specific; surrogate endpoints; meta regression ... See more keywords
Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5742-x
Abstract: BackgroundUsing a pathway-focused approach, we aimed to provide a subgroup-specific basis for finding novel therapeutic strategies and further refinement of the risk stratification in pediatric medulloblastoma.MethodBased on genome-wide Cox regression and Gene Set Enrichment Analysis,… read more here.
Keywords: subgroup; subgroup specific; group; expression ... See more keywords
HaploBlocker: Creation of Subgroup-Specific Haplotype Blocks and Libraries.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302283
Abstract: The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction... The… read more here.
Keywords: haploblocker creation; subgroup specific; genetics; creation subgroup ... See more keywords