Population pharmacokinetic modelling and simulation of fremanezumab in healthy subjects and patients with migraine
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14096
Abstract: Fremanezumab is a fully humanized IgG2Δa/κ monoclonal antibody specific for calcitonin gene‐related peptide developed and approved for the preventive treatment of migraine in adults. The population pharmacokinetics (PK) of fremanezumab were characterized in healthy subjects… read more here.
Keywords: population pharmacokinetic; subjects patients; pharmacokinetic modelling; healthy subjects ... See more keywords
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13317
Abstract: RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1 inhibition has been shown to… read more here.
Keywords: toxicology; ripk1; subjects patients; sar443060 ... See more keywords
Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Gastroenterology"
DOI: 10.2147/ceg.s271565
Abstract: Background The integrin α4β7 is highly expressed on activated T cells and is thought to direct homing of lymphocytes to the intestine. Since ulcerative colitis (UC) and Crohn’s disease (CD) are characterized by mucosal oligoclonal… read more here.
Keywords: repertoire; memory; cell; control subjects ... See more keywords