Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice.
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DOI: 10.1016/j.xphs.2018.06.029
Abstract: Protein aggregates are one of the several risk factors for undesired immunogenicity of biopharmaceuticals. However, it remains unclear which features determine whether aggregates will trigger an unwanted immune response. The aim of this study was… read more here.
Keywords: size particles; submicron size; soluble oligomers; micron size ... See more keywords