Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204786
Abstract: The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of treatments based on WJ‐MSCs. Exploration of WJ‐MSC heterogeneity with multimodal single‐cell technologies… read more here.
Keywords: subpopulation; cell; heterogeneity; single cell ... See more keywords
Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24064
Abstract: NG2 glia display wide proliferation and differentiation potential under physiological and pathological conditions. Here, we examined these two features following different types of brain disorders such as focal cerebral ischemia (FCI), cortical stab wound (SW),… read more here.
Keywords: astrocyte like; like ng2; ng2 glia; subpopulation ... See more keywords
Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.007
Abstract: SUMMARY T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly distinct… read more here.
Keywords: thymocytes molecularly; subpopulation; differentiation; single positive ... See more keywords
Evolutionary dynamics and the evolution of multiplayer cooperation in a subdivided population.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.06.034
Abstract: The classical models of evolution have been developed to incorporate structured populations using evolutionary graph theory and, more recently, a new framework has been developed to allow for more flexible population structures which potentially change… read more here.
Keywords: temperature; evolution; subpopulation; population ... See more keywords
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.02.037
Abstract: Antibiotics can induce mutations that cause antibiotic resistance. Yet, despite their importance, mechanisms of antibiotic-promoted mutagenesis remain elusive. We report that the fluoroquinolone antibiotic ciprofloxacin (cipro) induces mutations by triggering transient differentiation of a mutant-generating… read more here.
Keywords: response; subpopulation; cell subpopulation; reactive oxygen ... See more keywords
Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.03.021
Abstract: Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the… read more here.
Keywords: itch; differential coding; subpopulation; itch pain ... See more keywords
Critically Endangered subpopulation of Irrawaddy dolphin in central Philippines may lose its habitat to large-scale development project
Sign Up to like & getrecommendations! Published in 2020 at "Oryx"
DOI: 10.1017/s003060532000085x
Abstract: The Irrawaddy dolphin Orcaella brevirostris is a rangerestricted, facultative freshwater species that inhabits coastal, estuarine and freshwater habitats in disjunct populations from India to South-east Asia. The Iloilo-Guimaras Straits subpopulation is one of three known… read more here.
Keywords: irrawaddy dolphin; development; irrawaddy; subpopulation ... See more keywords
A high-frequency phenotypic switch links bacterial virulence and environmental survival in Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2018 at "Nature microbiology"
DOI: 10.1038/s41564-018-0151-5
Abstract: Antibiotic-resistant infections lead to 700,000 deaths per year worldwide1. The roles of phenotypically diverse subpopulations of clonal bacteria in the progression of diseases are unclear. We found that the increasingly pathogenic and antibiotic-resistant pathogen Acinetobacter… read more here.
Keywords: phenotypic switch; subpopulation; acinetobacter baumannii; acinetobacter ... See more keywords
IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1379642
Abstract: ABSTRACT Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological functions of other immune cells, such as dendritic cells and IFN-γ-producing… read more here.
Keywords: cell regulatory; cd73; subpopulation; development ... See more keywords
MicroRNA-135a-induced formation of CD133+ subpopulation with cancer stem cell properties in cervical cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa025
Abstract: Cancer stem cells (CSCs) play significant roles in tumor initiation. MicroRNA-135a (miR-135a) induced the formation of a CD133+ subpopulation from a human papillomavirus-immortalized cervical epithelial cell line. Compared with the CD133- cells, the CD133+ cells… read more here.
Keywords: cd133; 135a induced; formation; subpopulation ... See more keywords
P6420Can machine learning help us improve risk stratification of diabetic patients with acute coronary syndromes? The answer will blow your mind
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.1014
Abstract: Risk stratification following an acute coronary syndrome (ACS) is of utmost importance, in order to identify patients at higher risk of subsequent cardiovascular events. Diabetic patients have a significantly worse prognosis, so new risk prediction… read more here.
Keywords: stratification; risk; grace; diabetic patients ... See more keywords