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Published in 2019 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280218777538
Abstract: With the advent of personalized medicine, clinical trials studying treatment effects in subpopulations are receiving increasing attention. The objectives of such studies are, besides demonstrating a treatment effect in the overall population, to identify subpopulations,…
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Keywords:
confirmatory subpopulation;
biomarker;
subpopulation analyses;
procedures confirmatory ... See more keywords